Por favor, use este identificador para citar o enlazar este ítem:
https://hdl.handle.net/20.500.12008/42280
Cómo citar
Registro completo de metadatos
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Suárez, Gonzalo | - |
dc.contributor.author | Castells, Daniel | - |
dc.contributor.author | Imperiale, Fernanda | - |
dc.contributor.author | Fagiolino, Pietro | - |
dc.contributor.author | Canton, Candela | - |
dc.contributor.author | Lanusse, Carlos | - |
dc.contributor.author | Alvarez, Luis | - |
dc.date.accessioned | 2024-01-30T16:35:44Z | - |
dc.date.available | 2024-01-30T16:35:44Z | - |
dc.date.issued | 2023 | - |
dc.identifier.citation | Suárez, G., Castells, D., Imperiale, F., y otros. "Therapeutic advantages of the combined use of closantel and moxidectin in lambs parasitized with resistant gastrointestinal nematodes". International Journal for Parasitology: Drugs and Drug Resistance. [en línea] v.23, 2023. DOI: 10.1016/j.ijpddr.2023.07.004 | es |
dc.identifier.uri | https://hdl.handle.net/20.500.12008/42280 | - |
dc.description.abstract | The serious widespread development of nematode resistance has motivated the use of combined anthelmintic formulations. However, the advantages/disadvantages of the combined use of anthelmintics require further scientific characterization. The goals of the current trial were a) to characterize the pharmacokinetics of closantel (CLO) and moxidectin (MXD) administered both subcutaneously (sc) and orally either separately or co administered (CLO + MXD) to lambs; b) to compare the nematodicidal activity of both molecules given indi vidually or co-administered to lambs infected with resistant nematodes. Seventy (70) Corriedale lambs naturally infected with multiple resistant gastrointestinal nematodes were involved in the pharmacokinetic and efficacy trials. The animals were allocated into six groups (n = 10) and treated with either CLO, MXD, or with the CLO + MXD combined formulation by both the oral and sc routes. Additionally, an untreated control group (n = 10) was included for the efficacy trial. The efficacy was estimated by the faecal egg count reduction test (FECRT). Higher systemic exposure of both CLO and MXD was observed after the sc compared to the oral administration in lambs. The combined administration of CLO + MXD did not markedly alter their disposition kinetics. At 13 days post treatment, the administration of both molecules as a single active principle reached efficacy levels ranging be tween 80% (MXDoral), 84% (CLOoral), 85% (CLOsc), and 92% (MXDsc). The combined oral and sc treatments reached 99% efficacy. No adverse effects were observed after the combined treatment of CLO + MXD, and their co-administration did not show any adverse pharmacokinetic interaction. The combined effect of CLO + MXD successfully restored the maximum efficacy levels, which were not reached by the individual active ingredients. | es |
dc.format.extent | 9 p. | es |
dc.format.mimetype | application/pdf | es |
dc.language.iso | en | es |
dc.publisher | Elsevier | es |
dc.relation.ispartof | International Journal for Parasitology: Drugs and Drug Resistance, v.23, 2023. -- pp. 28-36 | es |
dc.rights | Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014) | es |
dc.subject.other | LACTONAS MACROCICLICAS | es |
dc.subject.other | FARMACOCINETICA | es |
dc.subject.other | OVEJAS | es |
dc.title | Therapeutic advantages of the combined use of closantel and moxidectin in lambs parasitized with resistant gastrointestinal nematodes | es |
dc.type | Artículo | es |
dc.contributor.filiacion | Suárez Gonzalo, Universidad de la República (Uruguay). Facultad de Veterinaria. Departamento de Clínicas y Hospital Veterinario. Unidad de Farmacología y Terapéutica | - |
dc.contributor.filiacion | Castells Daniel, Area de Investigación del Secretariado de la Lana (Uruguay) | - |
dc.contributor.filiacion | Imperiale Fernanda, Universidad Nacional del Centro de la Provincia de Buenos Aires (Argentina). Centro de Investigación Veterinaria de Tandil (CIVETAN), Facultad de Ciencias Veterinarias. Laboratorio de Farmacología | - |
dc.contributor.filiacion | Fagiolino Pietro, Universidad de la República (Uruguay). Facultad de Química. Departamento de Ciencias Farmacéuticas | - |
dc.contributor.filiacion | Canton Candela, Universidad Nacional del Centro de la Provincia de Buenos Aires (Argentina). Centro de Investigación Veterinaria de Tandil (CIVETAN), Facultad de Ciencias Veterinarias. Laboratorio de Farmacología | - |
dc.contributor.filiacion | Lanusse Carlos, Universidad Nacional del Centro de la Provincia de Buenos Aires (Argentina). Centro de Investigación Veterinaria de Tandil (CIVETAN), Facultad de Ciencias Veterinarias. Laboratorio de Farmacología | - |
dc.contributor.filiacion | Alvarez Luis, Universidad Nacional del Centro de la Provincia de Buenos Aires (Argentina). Centro de Investigación Veterinaria de Tandil (CIVETAN), Facultad de Ciencias Veterinarias. Laboratorio de Farmacología | - |
dc.rights.licence | Licencia Creative Commons Atribución - No Comercial - Sin Derivadas (CC - By-NC-ND 4.0) | es |
dc.identifier.doi | 10.1016/j.ijpddr.2023.07.004 | - |
Aparece en las colecciones: | Publicaciones académicas y científicas - Facultad de Química |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | ||
---|---|---|---|---|---|
Suárez, G. Internacional juornal for parasitology.pdf | Artículo | 679,9 kB | Adobe PDF | Visualizar/Abrir |
Este ítem está sujeto a una licencia Creative Commons Licencia Creative Commons