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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Watermeyer, Tam | - |
dc.contributor.author | Marroig, Alejandra | - |
dc.contributor.author | Ritchie, Craig W. | - |
dc.contributor.author | Ritchie, Karen | - |
dc.contributor.author | Blennow, Kaj | - |
dc.contributor.author | Muniz-Terrera, Graciela | - |
dc.date.accessioned | 2021-07-07T14:34:46Z | - |
dc.date.available | 2021-07-07T14:34:46Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | WATERMEYER, Tam, MARROIG, Alejandra, RITCHIE, Craig W., y otros."Cognitive dispersion is not associated with cerebrospinal fluid biomarkers of Alzheimer’s disease: results from the European Prevention of Alzheimer’s Dementia (EPAD) v500.0 Cohort". [Postprint]. Publicado en: Journal of Alzheimer’s disease [en línea]. 2020, Vol. 78, No.1, pp. 185-194. https://doi.org/10.3233/JAD-200514 | es |
dc.identifier.uri | https://hdl.handle.net/20.500.12008/28481 | - |
dc.description | Postprint (versión revisada por pares y aceptada para su publicación). | es |
dc.description.abstract | Background: Cognitive dispersion, variation in performance across cognitive domains, is posited as a non-invasive and cost-effective marker of early neurodegeneration. Little work has explored associations between cognitive dispersion and Alzheimer’s disease (AD) biomarkers in healthy older adults. Even less is known about the influence or interaction of biomarkers reflecting brain pathophysiology or other risk factors on cognitive dispersion scores. Objective: The main aim of this study was to examine whether higher cognitive dispersion was associated with cerebrospinal fluid (CSF) levels of amyloid β (Aβ42), total tau (t-tau), phosphorylated tau (p-tau) and amyloid positivity in a cohort of older adults at various severities of AD. A secondary aim was to explore which AD risk factors were associated with cognitive dispersion scores. Method: Linear and logistic regression analyses explored the associations between dispersion and CSF levels of Aβ42, t-tau and p-tau and amyloid positivity (Aβ42<1000pg/ml). Relationships between sociodemographics, APOEɛ4 status, family history of dementia and levels of depression and dispersion were also assessed. Results: Dispersion did not emerge as associated with any of the analytes nor amyloid positivity. Older (𝛽=−0.007,𝑆𝐸=0.002, p=0.001) and less educated (𝛽=−0.009,𝑆𝐸=0.003, p =0.009) individuals showed greater dispersion. Conclusion: Dispersion was not associated with AD pathology, but was associated with age and years of education, highlighting individual differences in cognitive ageing. The use of this metric as a screening tool for existing AD pathology is not supported by our analyses. Follow-up work will determine if dispersion scores can predict changes in biomarker levels and/or positivity status longitudinally. | es |
dc.format.mimetype | application/pdf | es |
dc.language.iso | en | es |
dc.publisher | IOS | es |
dc.relation.ispartof | Journal of Alzheimer’s disease, Vol. 78, No.1, pp. 185-194 | es |
dc.rights | Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014) | es |
dc.subject | Alzheimer’s disease | es |
dc.subject | Ageing | es |
dc.subject | Cognition | es |
dc.subject | Amyloid | es |
dc.subject | Tau | es |
dc.subject | Risk factors | es |
dc.subject | Enfermedad de Alzheimer | es |
dc.subject | Envejecimiento | es |
dc.subject | Cognición | es |
dc.subject | Amiloide | es |
dc.subject | Factores de riesgo | es |
dc.subject | Proteina tau | es |
dc.subject.other | EPIDEMIOLOGIA | es |
dc.subject.other | ANALISIS DE REGRESION | es |
dc.title | Cognitive dispersion is not associated with cerebrospinal fluid biomarkers of Alzheimer’s disease: results from the European Prevention of Alzheimer’s Dementia (EPAD) v500.0 Cohort | es |
dc.type | Artículo | es |
dc.contributor.filiacion | Watermeyer Tam, University of Edinburgh. Centre for Clinical Brain Sciences. Edinburgh Dementia Prevention | - |
dc.contributor.filiacion | Marroig Alejandra, Universidad de la República (Uruguay). Facultad de Ciencias Económicas y de Administración. Instituto de Estadística | - |
dc.contributor.filiacion | Ritchie Craig W., University of Edinburgh. Centre for Clinical Brain Sciences. Edinburgh Dementia Prevention | - |
dc.contributor.filiacion | Ritchie Karen, University of Edinburgh. Centre for Clinical Brain Sciences. Edinburgh Dementia Prevention | - |
dc.contributor.filiacion | Blennow Kaj, University of Gothenburg. Institute of Neuroscience and Physiology. Department of Psychiatry and Neurochemistry | - |
dc.contributor.filiacion | Muniz-Terrera Graciela, University of Edinburgh. Centre for Clinical Brain Sciences. Edinburgh Dementia Prevention | - |
dc.rights.licence | Licencia Creative Commons Atribución - No Comercial - Sin Derivadas (CC - By-NC-ND 4.0) | es |
dc.identifier.doi | https://doi.org/10.3233/JAD-200514 | - |
Aparece en las colecciones: | Artículos - Instituto de Estadística |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | ||
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Marroig_20_Cognitive_dispersion.pdf | Postprint | 439,83 kB | Adobe PDF | Visualizar/Abrir |
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