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Título: | New nitric oxide-releasing compounds as promising anti-bladder cancer drugs |
Autor: | Varela, María López, Miriam Ingold, Mariana Alem, Diego Perini, Valentina Perelmuter, Karen Bollati-Fogolín, Mariela López, Gloria V. Hernández, Paola |
Tipo: | Artículo |
Descriptores: | CANCER DE VEJIGA, FUROXANOS, OXIDO NITRICO |
Fecha de publicación: | 2023 |
Resumen: | Bladder cancer is a worldwide problem and improved therapies are urgently needed. In the search for newer strong antitumor compounds, herein, we present the study of three nitric oxide-releasing compounds and evaluate them as possible therapies for this malignancy. Bladder cancer cell lines T24 and 253J were used to evaluate the antiproliferative, antimigratory, and genotoxic effects of compounds. Moreover, we determined the NF-κB pathway inhibition, and finally, the survivin downregulation exerted by our molecules. The results revealed that compounds 1 and 3 exerted a high antiproliferative activity against bladder cancer cells through DNA damage and survivin downregulation. In addition, compound 3 reduced bladder cancer cell migration. We found that nitric oxide donors are promising molecules for the development of a new therapeutic targeting the underlying mechanisms of tumorigenesis and progression of bladder cancer. |
Editorial: | MDPI |
EN: | Biomedicines, v.11, n°1, 2023. -- 18 h. |
DOI: | https://doi.org/10.3390/biomedicines11010199 |
Citación: | Varela, M, López, M, Ingold, M, y otros. "New nitric oxide-releasing compounds as promising anti-bladder cancer drugs". Biomedicines. [en línea] 2023, vol.11, n°1, 18 h. DOI: https://doi.org/10.3390/biomedicines11010199 |
Licencia: | Licencia Creative Commons Atribución (CC - By 4.0) |
Aparece en las colecciones: | Publicaciones académicas y científicas - Facultad de Química |
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Fichero | Descripción | Tamaño | Formato | ||
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AA Varela, M. et al v.11 Biomedicines 2023.pdf | 5,13 MB | Adobe PDF | Visualizar/Abrir |
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