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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Fernández, Carlos Y. | - |
dc.contributor.author | Alvarez, Natalia | - |
dc.contributor.author | Rocha, Analu | - |
dc.contributor.author | Ellena, Javier | - |
dc.contributor.author | Costa-Filho, Antonio J. | - |
dc.contributor.author | Batista, Alzir A. | - |
dc.contributor.author | Facchin, Gianella | - |
dc.date.accessioned | 2023-11-06T12:08:43Z | - |
dc.date.available | 2023-11-06T12:08:43Z | - |
dc.date.issued | 2023 | - |
dc.identifier.citation | Fernández, C, Alvarez, N, Rocha, A, y otros. "New Copper(II)-L-Dipeptide-Bathophenanthroline complexes as potential anticancer agents—synthesis, characterization and cytotoxicity studies—and comparative DNA-Binding study of related phen complexes". Molecules. [en línea] 2023, vol.28, n°2, e896. DOI: https://doi.org/10.3390/molecules28020896 | es |
dc.identifier.uri | https://hdl.handle.net/20.500.12008/40934 | - |
dc.description.abstract | Searching for new copper compounds which may be useful as antitumor drugs, a series of new [Cu(L-dipeptide)(batho)] (batho:4,7-diphenyl-1,10-phenanthroline, L-dipeptide: Gly-Val, Gly-Phe, Ala-Gly, Ala-Ala, Ala-Phe, Phe-Ala, Phe-Val and Phe-Phe) complexes were synthesized and characterized. To interpret the experimental IR spectra, [Cu(ala-gly)(batho)] was modelled in the gas phase using DFT at the B3LYP/LANL2DZ level of theory and the calculated vibrational frequencies were analyzed. Solid-state characterization is in agreement with pentacoordinate complexes of the general formula [Cu(L-dipeptide)(batho)]·x solvent, similar to other [Cu(L-dipeptide)(diimine)] complexes. In solution, the major species are heteroleptic, as in the solid state. The mode of binding to the DNA was evaluated by different techniques, to understand the role of the diimine and the dipeptide. To this end, studies were also performed with complexes [CuCl2(diimine)], [Cu(L-dipeptide)(diimine)] and free diimines, with phenanthroline, neocuproine and 3,4,7,8-tetramethyl-phenanthroline. The cytotoxicity of the complexes was determined on human cancer cell lines MDA-MB-231, MCF-7 (breast, the first triple negative), and A549 (lung epithelial) and non-tumor cell lines MRC-5 (lung) and MCF-10A (breast). [Cu(L-dipeptide)(batho)] complexes are highly cytotoxic as compared to cisplatin and [Cu(L-dipeptide)(phenanthroline)] complexes, being potential candidates to study their in vivo activity in the treatments of aggressive tumors for which there is no curative pharmacological treatment. | es |
dc.format.mimetype | application/pdf | es |
dc.language.iso | en | es |
dc.publisher | MDPI | es |
dc.relation.ispartof | Molecules, v.28, n°2, 2023. -- e896 | es |
dc.rights | Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014) | es |
dc.subject.other | COMPLEJOS DE COBRE | es |
dc.subject.other | PEPTIDOS | es |
dc.subject.other | ADN | es |
dc.subject.other | ACTIVIDAD CITOTOXICA | es |
dc.subject.other | FENANTROLINA | es |
dc.title | New Copper(II)-L-Dipeptide-Bathophenanthroline complexes as potential anticancer agents—synthesis, characterization and cytotoxicity studies—and comparative DNA-Binding study of related phen complexes | es |
dc.type | Artículo | es |
dc.contributor.filiacion | Fernández Carlos Y., Universidad de la República (Uruguay). Facultad de Química; Programa de Posgrados de la Facultad de Química | - |
dc.contributor.filiacion | Alvarez Natalia, Universidad de la República (Uruguay). Facultad de Química | - |
dc.contributor.filiacion | Rocha Analu, Universidade Federal de São Carlos (Brasil). Departamento de Química | - |
dc.contributor.filiacion | Ellena Javier, Universidade de São Paulo (Brasil). Instituto de Física de São Carlos | - |
dc.contributor.filiacion | Costa-Filho Antonio J., Universidade de São Paulo (Brasil). Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto | - |
dc.contributor.filiacion | Batista Alzir A., Universidade Federal de São Carlos (Brasil). Departamento de Química | - |
dc.contributor.filiacion | Facchin Gianella, Universidad de la República (Uruguay). Facultad de Química | - |
dc.rights.licence | Licencia Creative Commons Atribución (CC - By 4.0) | es |
dc.identifier.doi | https://doi.org/10.3390/molecules28020896 | - |
Aparece en las colecciones: | Publicaciones académicas y científicas - Facultad de Química |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | ||
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AA Fernández, C. Y. et al v.28 Molecules 2023.pdf | 1,72 MB | Adobe PDF | Visualizar/Abrir |
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