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| Título: | Organocatalytic synthesis and Anti-Trypanosomal activity evaluation of L-Pentofuranose-Mimetic iminosugars |
| Autor: | Mesa, Juan M. Comini, Marcelo A. Dibello, Estefanía Gamenara, Daniela |
| Tipo: | Artículo |
| Palabras clave: | CARBOHIDRATOS, INMINOAZUCAR, TRYPANOSOMA BRUCEI, REACCION DE MANNICH, ORGANOCATALISIS |
| Fecha de publicación: | 2022 |
| Resumen: | A series of L-lyxo and L-xylo- pentofuranose-mimetic iminosugars and derivatives were efficiently synthesized in a stereoselective manner, through a concise strategy which involves an organocatalyzed Mannich reaction of an imine and a protected dioxanone as key step, using D-proline as catalyst. A preliminary evaluation of their activity as potential anti-trypanosomal agents was studied. One of the synthesized compounds showed an interesting activity against bloodstream Trypanosoma brucei brucei (EC,)=3.8 + 1.0 1M). |
| Descripción: | Versión aceptada (Postprint) |
| Editorial: | Wiley |
| EN: | European Journal of Organic Chemistry, v.34, 2022. -- e202200636 |
| DOI: | 10.1002/ejoc.202200636 |
| Citación: | Mesa, J, Comini, M, Dibello, E y Gamenara, D. "Organocatalytic synthesis and Anti-Trypanosomal activity evaluation of L-Pentofuranose-Mimetic iminosugars". European Journal of Organic Chemistry. [en línea] 2022 v.34, 2022. -- e202200636 .. 7 p.. |
| Licencia: | Licencia Creative Commons Atribución - No Comercial - Sin Derivadas (CC - By-NC-ND 4.0) |
| Aparece en las colecciones: | Publicaciones académicas y científicas - Facultad de Química |
Ficheros en este ítem:
| Fichero | Descripción | Tamaño | Formato | ||
|---|---|---|---|---|---|
| Eur J Org Chem_2022_Mesa.pdf | Preprint | 1,07 MB | Adobe PDF | Visualizar/Abrir |
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