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Por favor, use este identificador para citar o enlazar este ítem: https://hdl.handle.net/20.500.12008/51912 Cómo citar
Título: Pathological Study of Demyelination with Cellular Reactions in the Cerebellum of Dogs Infected with Canine Distemper Virus
Autor: Verdes García, José Manuel
Larrañaga Sposito, Camila
Godiño Morales, Guillermo Jesús
Varela Cruces, María Belén
Yozzi, Victoria
Iribarnegaray Perera, María Victoria
Delucchi, Luis
Yamasaki, Kanji
Tipo: Artículo
Descriptores: PERROS, PEQUEÑOS ANIMALES, VIROSIS, CEREBELO, DESMIELINIZACION
Fecha de publicación: 2024
Resumen: The purpose of this study was to examine the relationship between demyelination and cellular reactions in the cerebellum of Canine Distemper Virus (CDV)-infected dogs. We subdivided the disease staging by adding the degree of demyelination determined by Luxol Fast Blue staining to the previously reported disease staging from the acute stage to the chronic stage, and investigated the relationship between demyelination in the cerebellum and the number and histological changes in astroglia, microglia, and Purkinje cells in each stage. Reactions of astrocytes and microglia were observed at an early stage when demyelination was not evident. Changes progressed with demyelination. Demyelination initially began in the medulla adjoining the fourth ventricle and gradually spread to the entire cerebellum, including the lobes. CDV immune-positive granules were seen from the early stage, and inclusion bodies also appeared at the same time. CDV immune-positive reaction and inclusion bodies were observed in astrocytes, microglia, neurons, ependymal cells, and even leptomeningeal mononuclear cells. On the other hand, infiltration of CDV-immunoreactive particles from the pia mater to the gray matter and further into the white matter through the granular layer was observed from an early stage. Purkinje cells decreased from the intermediate stage, and a decrease in cells in the granular layer was also observed. There was no clear association between age and each stage, and the stages did not progress with age.
EN: Viruses, 2024, 16(11), 1719, 1-15
Financiadores: ANII
Citación: Verdes García, J, Larrañaga Sposito, C, Godiño Morales, G, Varela Cruces, M, Yozzi, V, Iribarnegaray Perera, M, Delucchi, L y Yamasaki, K. Pathological Study of Demyelination with Cellular Reactions in the Cerebellum of Dogs Infected with Canine Distemper Virus. Viruses. [en línea] 2024, 16(11), 1719, 1-15
Licencia: Licencia Creative Commons Atribución (CC - By 4.0)
Aparece en las colecciones: Publicaciones académicas y científicas - Facultad de Veterinaria

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