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Por favor, use este identificador para citar o enlazar este ítem: https://hdl.handle.net/20.500.12008/50891 Cómo citar
Título: Mucins Shed from the Laminated Layer in Cystic Echinococcosis Are Captured by Kupffer Cells via the Lectin Receptor Clec4F
Autor: Barrios, Anabella A.
Mouhape, Camila
Schreiber, Leonard
Zhang, Linyun
Nell, Juliane
Suárez-Martins, Mariana
Schlapp, Geraldine
Meikle, María Noel
Mulet, Ana Paula
Hsu, Tsui-Ling
Hsieh, Shie-Liang
Mourglia-Ettlin, Gustavo
González, Carlos
Crispo, Martina
Barth, Thomas F. E.
Casaravilla, Cecilia
Jenkins, Stephen J.
Díaz, Álvaro
Tipo: Artículo
Palabras clave: Echinococcus, Laminated layer, Lectin, Mucin, Kupffer cells, Clec4F
Fecha de publicación: 2023
Resumen: Cystic echinococcosis is caused by the larval stages (hydatids) of cestode parasites belonging to the species cluster Echinococcus granulosus sensu lato, with E. granulosus sensu stricto being the main infecting species. Hydatids are bladderlike structures that attain large sizes within various internal organs of livestock ungulates and humans. Hydatids are protected by the massive acellular laminated layer (LL), composed mainly of mucins. Parasite growth requires LL turnover, and abundant LL-derived particles are found at infection sites in infected humans, raising the question of how LL materials are dealt with by the hosts. In this article, we show that E. granulosus sensu stricto LL mucins injected into mice are taken up by Kupffer cells, the liver macrophages exposed to the vascular space. This uptake is largely dependent on the intact mucin glycans and on Clec4F, a C-type lectin receptor which, in rodents, is selectively expressed in Kupffer cells. This uptake mechanism operates on mucins injected both in soluble form intravenously (i.v.) and in particulate form intraperitoneally (i.p.). In mice harboring intraperitoneal infections by the same species, LL mucins were found essentially only at the infection site and in the liver, where they were taken up by Kupffer cells via Clec4F. Therefore, shed LL materials circulate in the host, and Kupffer cells can act as a sink for these materials, even when the parasite grows in sites other than the liver.
EN: Infect. Immun. 91(6), 2023
Financiadores: Agencia Nacional de Investigación e Innovación (ANII)
Comisión Sectorial de Investigación Científica (CSIC)
Programa de Desarrollo de las Ciencias Básicas (PEDEClBA)
Citación: BARRIOS, AA., MOUHAPE, C., SCHREIBER, L., y otros. Mucins Shed from the Laminated Layer in Cystic Echinococcosis Are Captured by Kupffer Cells via the Lectin Receptor Clec4F. Infect. Immun [en línea] 2023, 91(6). DOI: 10.1128/iai.00031-23
Licencia: Licencia Creative Commons Atribución (CC - By 4.0)
Aparece en las colecciones: Artículos - Instituto de Higiene

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