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Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12008/48338 How to cite
Title: Trypanosoma cruzi Isolates Naturally Adapted to Congenital Transmission Display a Unique Strategy of Transplacental Passage
Authors: Faral-Tello, Paula
Greif, Gonzalo
Romero, Selva
Cabrera Castro, Andrés M.
Oviedo, Cristina
González, Telma
Libisch Recalde, María Gabriela
Arévalo, Ana Paula
Varela Cruces, María Belén
Verdes García, José Manuel
Crispo, Martina
Basmadjian, Yester
Robello Porto, Carlos
Type: Artículo
Descriptors: ENFERMEDAD DE CHAGAS, TRYPANOSOMA CRUZI, TRANSMISION VERTICAL
Issue Date: 2023
Abstract: Chagas disease is mainly transmitted by vertical transmission (VT) in nonendemic areas and in endemic areas where vector control programs have been successful. For the present study, we isolated natural Trypanosoma cruzi strains vertically transmitted through three generations and proceeded to study their molecular mechanism of VT using mice. No parasitemia was detected in immunocompetent mice, but the parasites were able to induce an immune response and colonize different organs. VT experiments revealed that infection with different strains did not affect mating, pregnancy, or resorption, but despite low parasitemia, VT strains reached the placenta and resulted in higher vertical transmission rates than strains of either moderate or high virulence. While the virulent strain modulated more than 2,500 placental genes, VT strains modulated 150, and only 29 genes are shared between them. VT strains downregulated genes associated with cell division and replication and upregulated immunomodulatory genes, leading to anti-inflammatory responses and tolerance. The virulent strain stimulated a strong proinflammatory immune response, and this molecular footprint correlated with histopathological analyses. We describe a unique placental response regarding the passage of T. cruzi VT isolates across the maternal-fetal interphase, challenging the current knowledge derived mainly from studies of laboratory-adapted or highly virulent strains.
IN: Microbiology Spectrum, 2023, 11(2), 1-21
Citation: Faral-Tello, P, Greif, G, Romero, S, Cabrera Castro, A, Oviedo, C, González, T, Libisch Recalde, M, Arévalo, A, Varela Cruces, M, Verdes García, J, Crispo, M, Basmadjian, Y y Robello Porto, C. Trypanosoma cruzi Isolates Naturally Adapted to Congenital Transmission Display a Unique Strategy of Transplacental Passage. Microbiology Spectrum. [en línea] 2023, 11(2), 1-21
Appears in Collections:Publicaciones académicas y científicas - Facultad de Veterinaria

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