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Título: | Multiple introductions and onward transmission of non-pandemic HIV-1 subtype B strains in North America and Europe |
Autor: | Cabello, M. Romero Brunetto, Héctor Gabriel Bello, Gonzalo |
Tipo: | Artículo |
Palabras clave: | Virus, HIV, Transmission of infections |
Fecha de publicación: | 2016 |
Resumen: | Most HIV-1 subtype B infections in North America and Europe seem to have resulted from the expansion of a single pandemic lineage (B PANDEMIC) disseminated from the United States (US). Some non-pandemic subtype B strains of Caribbean origin (B CAR) may have also reached North America and Europe, but their epidemiological relevance in those regions remains largely unknown. Here we analyze a total of 20,045 HIV-1 subtype B pol sequences from the US, Canada, and Europe, to estimate the prevalence and to reconstruct the spatiotemporal dynamics of dissemination of HIV-1 B CAR strains in those regions. We find that B CAR strains were probably disseminated from the Caribbean into North America and Europe at multiple times since the early 1970s onwards. The B CAR strains reached the US, Canada and at least 16 different European countries, where they account for a very low fraction (<5%) of subtype B infections, with exception of the Czech Republic (7.7%). We also find evidence of the onward transmission of B CAR clades in the US, Canada, the Czech Republic, Germany, Italy, Spain and the UK, as well as short-distance spreading of B CAR lineages between neighboring European countries from Central and Western Europe, and long-distance dissemination between the US and Europe. |
Editorial: | Nature Publishing Group |
EN: | Scientific Reports, 2016, 6, art. no. 33971 |
DOI: | 10.1038/srep33971 |
ISSN: | 2045-2322 |
Citación: | Cabello, M., Romero, H., Bello, G. Multiple introductions and onward transmission of non-pandemic HIV-1 subtype B strains in North America and Europe. Scientific Reports, 2016, 6, art. nro. 33971. doi: 10.1038/srep33971 |
Licencia: | Licencia Creative Commons Atribución (CC –BY 4.0) |
Aparece en las colecciones: | Publicaciones académicas y científicas - Facultad de Ciencias |
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101038srep33971.pdf | 2,14 MB | Adobe PDF | Visualizar/Abrir |
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