Por favor, use este identificador para citar o enlazar este ítem:
https://hdl.handle.net/20.500.12008/22010
Cómo citar
Registro completo de metadatos
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Cabello, M. | es |
dc.contributor.author | Romero Brunetto, Héctor Gabriel | es |
dc.contributor.author | Bello, Gonzalo | es |
dc.date.accessioned | 2019-10-02T22:08:25Z | - |
dc.date.available | 2019-10-02T22:08:25Z | - |
dc.date.issued | 2016 | es |
dc.date.submitted | 20190930 | es |
dc.identifier.citation | Cabello, M., Romero, H., Bello, G. Multiple introductions and onward transmission of non-pandemic HIV-1 subtype B strains in North America and Europe. Scientific Reports, 2016, 6, art. nro. 33971. doi: 10.1038/srep33971 | es |
dc.identifier.issn | 2045-2322 | es |
dc.identifier.uri | https://hdl.handle.net/20.500.12008/22010 | - |
dc.description.abstract | Most HIV-1 subtype B infections in North America and Europe seem to have resulted from the expansion of a single pandemic lineage (B PANDEMIC) disseminated from the United States (US). Some non-pandemic subtype B strains of Caribbean origin (B CAR) may have also reached North America and Europe, but their epidemiological relevance in those regions remains largely unknown. Here we analyze a total of 20,045 HIV-1 subtype B pol sequences from the US, Canada, and Europe, to estimate the prevalence and to reconstruct the spatiotemporal dynamics of dissemination of HIV-1 B CAR strains in those regions. We find that B CAR strains were probably disseminated from the Caribbean into North America and Europe at multiple times since the early 1970s onwards. The B CAR strains reached the US, Canada and at least 16 different European countries, where they account for a very low fraction (<5%) of subtype B infections, with exception of the Czech Republic (7.7%). We also find evidence of the onward transmission of B CAR clades in the US, Canada, the Czech Republic, Germany, Italy, Spain and the UK, as well as short-distance spreading of B CAR lineages between neighboring European countries from Central and Western Europe, and long-distance dissemination between the US and Europe. | es |
dc.format.mimetype | application/pdf | es |
dc.language.iso | en | es |
dc.publisher | Nature Publishing Group | es |
dc.relation.ispartof | Scientific Reports, 2016, 6, art. no. 33971 | es |
dc.rights | Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad De La República. (Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014) | es |
dc.subject | Virus | es |
dc.subject | HIV | - |
dc.subject | Transmission of infections | - |
dc.title | Multiple introductions and onward transmission of non-pandemic HIV-1 subtype B strains in North America and Europe | es |
dc.type | Artículo | es |
dc.contributor.filiacion | Romero, Héctor. Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología. | es |
dc.rights.licence | Licencia Creative Commons Atribución (CC –BY 4.0) | es |
dc.identifier.doi | 10.1038/srep33971 | es |
Aparece en las colecciones: | Publicaciones académicas y científicas - Facultad de Ciencias |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | ||
---|---|---|---|---|---|
101038srep33971.pdf | 2,14 MB | Adobe PDF | Visualizar/Abrir |
Este ítem está sujeto a una licencia Creative Commons Licencia Creative Commons