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| Título: | Genetics of Latin American Diversity Project: Insights into population genetics and association studies in admixed groups in the Americas |
| Autor: | Borda, Víctor Loesch, Douglas P. Guo, Bing Dieguez, Elena Raggio, Víctor |
| Tipo: | Artículo |
| Palabras clave: | GLAD-match, GWAS, Latin America, Identity-by-descent, Imputation, Local ancestry, Migration, Population structure |
| Descriptores: | GENÉTICA, ALGORITMOS, VARIACIÓN GENÉTICA, GENÉTICA DE POBLACIÓN, HUMANOS, ESTUDIO DE ASOCIACIÓN DEL GENOMA COMPLETO, HAPLOTIPOS, PROGRAMAS INFORMÁTICOS |
| Fecha de publicación: | 2024 |
| Resumen: | Latin Americans are underrepresented in genetic studies, increasing disparities in personalized genomic medicine. Despite available genetic data from thousands of Latin Americans, accessing and navigating the bureaucratic hurdles for consent or access remains challenging. To address this, we introduce the Genetics of Latin American Diversity (GLAD) Project, compiling genome-wide information from 53,738 Latin Americans across 39 studies representing 46 geographical regions. Through GLAD, we identified heterogeneous ancestry composition and recent gene flow across the Americas. Additionally, we developed GLAD-match, a simulated annealing-based algorithm, to match the genetic background of external samples to our database, sharing summary statistics (i.e., allele and haplotype frequencies) without transferring individual-level genotypes. Finally, we demonstrate the potential of GLAD as a critical resource for evaluating statistical genetic software in the presence of admixture. By providing this resource, we promote genomic research in Latin Americans and contribute to the promises of personalized medicine to more people. |
| Descripción: | Victor Borda 1, Douglas P Loesch 2, Bing Guo 2, Roland Laboulaye 2, Diego Veliz-Otani 2, Jennifer N French 2, Thiago Peixoto Leal 3, Stephanie M Gogarten 4, Sunday Ikpe 2, Mateus H Gouveia 5, Marla Mendes 6, Gonçalo R Abecasis 7, Isabela Alvim 6, Carlos E Arboleda-Bustos 8, Gonzalo Arboleda 8, Humberto Arboleda 8, Mauricio L Barreto 9, Lucas Barwick 10, Marcos A Bezzera 11, John Blangero 12, Vanderci Borges 13, Omar Caceres 14, Jianwen Cai 15, Pedro Chana-Cuevas 16, Zhanghua Chen 17, Brian Custer 18, Michael Dean 19, Carla Dinardo 20, Igor Domingos 11, Ravindranath Duggirala 12, Elena Dieguez 21, Willian Fernandez 8, Henrique B Ferraz 13, Frank Gilliland 17, Heinner Guio 22, Bernardo Horta 23, Joanne E Curran 12, Jill M Johnsen 24, Robert C Kaplan 25, Shannon Kelly 26, Eimear E Kenny 27, Barbara A Konkle 28, Charles Kooperberg 29, Andres Lescano 21, M Fernanda Lima-Costa 30, Ruth J F Loos 31, Ani Manichaikul 32, Deborah A Meyers 33, Michel S Naslavsky 34, Deborah A Nickerson 35, Kari E North 36, Carlos Padilla 37, Michael Preuss 27, Victor Raggio 38, Alexander P Reiner 39, Stephen S Rich 32, Carlos R Rieder 40, Michiel Rienstra 41, Jerome I Rotter 42, Tatjana Rundek 43, Ralph L Sacco 43, Cesar Sanchez 37, Vijay G Sankaran 44, Bruno Lopes Santos-Lobato 45, Artur Francisco Schumacher-Schuh 46, Marilia O Scliar 34, Edwin K Silverman 47, Tamar Sofer 48, Jessica Lasky-Su 47, Vitor Tumas 49, Scott T Weiss 47; Latin American Research Consortium on the Genetics of Parkinson’s Disease (LARGE-PD); National Institute of Neurological Disorders and Stroke (NINDS) Stroke Genetics Network (SiGN) Consortium; Trans-Omics for Precision Medicine (TOPMed) Population Genetics Working Group; Ignacio F Mata 50, Ryan D Hernandez 51, Eduardo Tarazona-Santos 52, Timothy D O'Connor 53 Affiliations 1Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD 21201, USA; University of Maryland Institute for Health Computing, University of Maryland School of Medicine, North Bethesda, MD 20852, USA. Electronic address: vicbp1@gmail.com. 2Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD 21201, USA. 3Lerner Research Institute, Genomic Medicine, Cleveland Clinic, Cleveland, OH, USA. 4Department of Biostatistics, University of Washington, Seattle, WA, USA. 5Center for Research on Genomics and Global Health, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA. 6Department of Genetics, Ecology, and Evolution, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. 7Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA. 8Neuroscience and Cell Death Research Groups, Medical School and Genetic Institute, Universidad Nacional de Colombia, Bogota, Colombia. 9Instituto de Saúde Coletiva, Universidade Federal da Bahia, Salvador, BA 40110-040, Brazil. 10LTRC Data Coordinating Center, The Emmes Company, Rockville, MD, USA. 11Department of Genetics, Federal University of Pernambuco, Av. Prof. Moraes Rego, 1235, Recife, PE 50670-901, Brazil. 12Department of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA. 13Movement Disorders Unit, Department of Neurology and Neurosurgery, Universidade Federal de São Paulo, São Paulo, Brazil. 14Instituto Nacional de Salud, Lima, Peru; Facultad de Ciencias de la Salud, Universidad Científica del Sur, Lima, Peru. 15Department of Biostatistics, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. 16CETRAM, Facultad de Ciencias Médicas, Universidad de Santiago de Chile, Santiago, Chile. 17Keck School of Medicine, University of Southern California, Los Angeles, Los Angeles, CA, USA. 18Vitalant Research Institute, San Francisco, CA, USA. 19Laboratory of Genomic Diversity, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD, USA. 20Instituto de Medicina Tropical, University of São Paulo, São Paulo, Brazil. 21Neurology Institute, Universidad de la República, Montevideo, Uruguay. 22Instituto Nacional de Salud, Lima, Peru; INBIOMEDIC Research Center, Lima, Peru; Universidad de Huánuco, Huánuco, Peru. 23Faculdade de Medicina, Departamento de Medicina Social, Universidade Federal de Pelotas, Pelotas, RS, Brazil. 24Bloodworks Northwest Research Institute, Seattle, WA, USA. 25Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA. 26Vitalant Research Institute, San Francisco, CA, USA; UCSF Benioff Children's Hospital, University of California, San Francisco, Oakland, CA, USA. 27Icahn School of Medicine at Mount Sinai, New York, NY, USA. 28Department of Medicine, University of Washington, Seattle, WA, USA. 29Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA. 30Instituto de Pesquisas René Rachou, Fundação Oswaldo Cruz, Belo Horizonte, MG, Brazil. 31The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 32Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA. 33Division of Genetics, Genomics, and Precision Medicine, University of Arizona, Tucson, AZ, USA. 34Human Genome and Stem Cell Research Center, University of São Paulo, São Paulo, SP, Brazil. 35Department of Genome Sciences, University of Washington, Seattle, WA, USA. 36Department of Epidemiology, Gillings School of Global Public Health, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. 37Instituto Nacional de Salud, Lima, Peru. 38Genetics Department, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay. 39Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA; Department of Epidemiology, University of Washington, Seattle, WA, USA. 40Departamento de Neurologia, Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, Brazil. 41Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. 42The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA USA. 43Department of Neurology, Miller School of Medicine, and The Evelyn F. McKnight Brain Institute, University of Miami, Miami, FL, USA. 44Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA. 45Instituto de Ciências da Saúde, Universidade Federal do Pará, Belém, Brazil. 46Departamento de Farmacologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil; Serviço de Neurologia, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil. 47Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA. 48Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Harvard Medical School, Boston, MA USA. 49Ribeirão Preto Medical School, Universidade de São Paulo, Ribeirão Preto, Brazil. 50University of Maryland Institute for Health Computing, University of Maryland School of Medicine, North Bethesda, MD 20852, USA. 51Institute for Human Genetics, University of California, San Francisco, San Francisco, CA, USA; Bakar Computational Health Sciences Institute, University of California, San Francisco, San Francisco, CA, USA; Quantitative Biosciences Institute, University of California, San Francisco, San Francisco, CA, USA; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA 94143, USA. 52Department of Genetics, Ecology, and Evolution, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil; Facultad de Salud Pública y Administración. Universidad Peruana Cayetano Heredia, Lima, Peru. 53Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD 21201, USA; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA; Program in Health Equity and Population Health, University of Maryland School of Medicine, Baltimore, MD 21201, USA; Program in Personalized Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA. Electronic address: timothydoconnor@gmail.com. |
| Editorial: | Elsevier |
| EN: | Cell Genomics. 2024;4(11) |
| Citación: | Borda V, Loesch D, Guo B y otros. Genetics of Latin American Diversity Project: Insights into population genetics and association studies in admixed groups in the Americas. Cell Genomics [en línea]. 2024;4(11). 26 p. |
| Cobertura geográfica: | AMÉRICA LATINA |
| Licencia: | Licencia Creative Commons Atribución - No Comercial - Sin Derivadas (CC - By-NC-ND 4.0) |
| Aparece en las colecciones: | Publicaciones Académicas y Científicas - Facultad de Medicina |
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