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dc.contributor.authorTraglia, Germán Matías-
dc.contributor.authorPasteran, Fernando-
dc.contributor.authorEscalante, Jenny-
dc.contributor.authorNishimura, Brent-
dc.contributor.authorTuttobene, Marisel R.-
dc.contributor.authorSubils, Tomás-
dc.contributor.authorNuñez, María Rosa-
dc.contributor.authorRivollier, María Gabriela-
dc.contributor.authorCorso, Alejandra-
dc.contributor.authorTolmasky, Marcelo E.-
dc.contributor.authorRamírez, María Soledad-
dc.date.accessioned2026-03-26T15:45:41Z-
dc.date.available2026-03-26T15:45:41Z-
dc.date.issued2023-
dc.identifier.citationTraglia G, Pasteran F, Escalante J y otros. Genomic Comparative Analysis of Two Multi-Drug Resistance (MDR) Acinetobacter baumannii Clinical Strains Assigned to International Clonal Lineage II Recovered Pre- and Post-COVID-19 Pandemic. Biology [en línea]. 2023;12(3). 14 p.es
dc.identifier.urihttps://hdl.handle.net/20.500.12008/54149-
dc.description.abstractBackground: After the emergence of COVID-19, numerous cases of A. baumannii/SARS-CoV-2 co-infection were reported. Whether the co-infecting A. baumannii strains have distinctive characteristics remains unknown. Methods and results: A. baumannii AMA_NO was isolated in 2021 from a patient with COVID-19. AMA166 was isolated from a mini-BAL used on a patient with pneumonia in 2016. Both genomes were similar, but they possessed 337 (AMA_NO) and 93 (AMA166) unique genes that were associated with biofilm formation, flagellar assembly, antibiotic resistance, secretion systems, and other functions. The antibiotic resistance genes were found within mobile genetic elements. While both strains harbored the carbapenemase-coding gene blaOXA-23, only the strain AMA_NO carried blaNDM-1. Representative functions coded for by virulence genes are the synthesis of the outer core of lipooligosaccharide (OCL5), biosynthesis and export of the capsular polysaccharide (KL2 cluster), high-efficiency iron uptake systems (acinetobactin and baumannoferrin), adherence, and quorum sensing. A comparative phylogenetic analysis including 239 additional sequence type (ST) 2 representative genomes showed high similarity to A. baumannii ABBL141. Since the degree of similarity that was observed between A. baumannii AMA_NO and AMA166 is higher than that found among other ST2 strains, we propose that they derive from a unique background based on core-genome phylogeny and comparative genome analysis. Conclusions: Acquisition or shedding of specific genes could increase the ability of A. baumannii to infect patients with COVID-19.es
dc.format.extent14 p.es
dc.format.mimetypeapplication/pdfes
dc.language.isoenes
dc.publisherMDPIes
dc.relation.ispartofBiology. 2023;12(3)es
dc.rightsLas obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014)es
dc.subjectAcinetobacter baumannii MDRes
dc.subjectCOVID-19es
dc.subjectST-2es
dc.subjectblaNDM-1es
dc.subjectblaOXA-23es
dc.subject.otherGENESes
dc.subject.otherFARMACORRESISTENCIA BACTERIANAes
dc.subject.otherGENOMAes
dc.subject.otherESTUDIO COMPARATIVOes
dc.subject.otherANTIBACTERIANOSes
dc.titleGenomic Comparative Analysis of Two Multi-Drug Resistance (MDR) Acinetobacter baumannii Clinical Strains Assigned to International Clonal Lineage II Recovered Pre- and Post-COVID-19 Pandemices
dc.typeArtículoes
dc.contributor.filiacionTraglia Germán Matías, Universidad de la República (Uruguay). Facultad de Medicina. Instituto de Higiene, Departamento de Desarrollo Biotecnológico-
dc.contributor.filiacionPasteran Fernando, Instituto Nacional de Enfermedades Infecciosas ANLIS Dr. Carlos G. Malbrán (Argentina). Servicio Antimicrobianos-
dc.contributor.filiacionEscalante Jenny, California State University Fullerton (E.E.U.U.). College of Natural Sciences and Mathematics, Department of Biological Science-
dc.contributor.filiacionNishimura Brent, California State University Fullerton (E.E.U.U.). College of Natural Sciences and Mathematics, Department of Biological Science-
dc.contributor.filiacionTuttobene Marisel R., Instituto de Biología Molecular y Celular de Rosario (Argentina)-
dc.contributor.filiacionSubils Tomás, Instituto de Procesos Biotecnológicos y Químicos de Rosario (Argentina)-
dc.contributor.filiacionNuñez María Rosa, Hospital Provincial Neuquén Dr. Castro Rendón (Argentina). Laboratorio de Microbiología-
dc.contributor.filiacionRivollier María Gabriela, Hospital Artémides Zatti (Argentina). Laboratorio de Microbiología-
dc.contributor.filiacionCorso Alejandra, Instituto Nacional de Enfermedades Infecciosas ANLIS Dr. Carlos G. Malbrán (Argentina). Servicio Antimicrobianos-
dc.contributor.filiacionTolmasky Marcelo E., California State University Fullerton (E.E.U.U.). College of Natural Sciences and Mathematics, Department of Biological Science-
dc.contributor.filiacionRamírez María Soledad, California State University Fullerton (E.E.U.U.). College of Natural Sciences and Mathematics, Department of Biological Science-
dc.rights.licenceLicencia Creative Commons Atribución (CC - By 4.0)es
dc.identifier.doi10.3390/biology12030358-
dc.identifier.eissn2079-7737-
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