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| Título: | Biomarkers for dementia in Latin American countries: Gaps and opportunities |
| Autor: | Parra, Mario A. Orellana, Paulina Cabello Gonzalez, Victoria León, Tomás Henriquez, Fernando Gómez, Rodrigo Ávalos, Constanza Damian, Andrés Slachevsky, Andrea Ibáñez, Agustín Contreras, Valeria Dansilio, Sergio Kmaid, Ana |
| Tipo: | Artículo |
| Descriptores: | DEMENCIA, DIGNÓSTICO, ENFERMEDAD DE ALZHEIMER, BIOMARCADORES |
| Fecha de publicación: | 2023 |
| Resumen: | Limited knowledge on dementia biomarkers in Latin American and Caribbean (LAC) countries remains a serious barrier. Here, we reported a survey to explore the ongoing work, needs, interests, potential barriers, and opportunities for future studies related to biomarkers. The results show that neuroimaging is the most used biomarker (73%), followed by genetic studies (40%), peripheral fluids biomarkers (31%), and cerebrospinal fluid biomarkers (29%). Regarding barriers in LAC, lack of funding appears to undermine the implementation of biomarkers in clinical or research settings, followed by insufficient infrastructure and training. The survey revealed that despite the above barriers, the region holds a great potential to advance dementia biomarkers research. Considering the unique contributions that LAC could make to this growing field, we highlight the urgent need to expand biomarker research. These insights allowed us to propose an action plan that addresses the recommendations for a biomarker framework recently proposed by regional experts. |
| Descripción: | Mario A Parra 1, Paulina Orellana 2 3, Tomas Leon 4 5, Cabello G Victoria 2 6 7, Fernando Henriquez 6 8 9, Rodrigo Gomez 5 10, Constanza Avalos 2 3, Andres Damian 11, Andrea Slachevsky 5 6 8 12, Agustin Ibañez 2 3 4 13 14, Henrik Zetterberg 15 16 17 18 19, Betty M Tijms 20, Jennifer S Yokoyama 13 21, Stefanie D Piña-Escudero 22, J Nicholas Cochran 23, Diana L Matallana 24 25 26, Daisy Acosta 27, Ricardo Allegri 28 29, Bianca P Arias-Suárez 30, Bernardo Barra 31 32, Maria Isabel Behrens 12 33 34 35, Sonia M D Brucki 36, Geraldo Busatto 37, Paulo Caramelli 38, Sheila Castro-Suarez 22 39, Valeria Contreras 40, Nilton Custodio 41, Sergio Dansilio 42, Myriam De la Cruz-Puebla 13 43 44 45, Leonardo Cruz de Souza 37 46, Monica M Diaz 47 48, Lissette Duque 49, Gonzalo A Farías 33, Sergio T Ferreira 50, Nahuel Magrath Guimet 22 28, Ana Kmaid 51, David Lira 41, Francisco Lopera 52, Beatriz Mar Meza 22 53, Eliane C Miotto 36, Ricardo Nitrini 36, Alberto Nuñez 49, Santiago O'Neill 54, John Ochoa 55, Maritza Pintado-Caipa 22 41, Elisa de Paula França Resende 13 38 46 56 57, Shannon Risacher 58, Luz Angela Rojas 59, Valentina Sabaj 60, Lucas Schilling 46 56 61, Allis F Sellek 62, Ana Sosa 63, Leonel T Takada 36, Antonio L Teixeira 64 65, Martha Unaucho-Pilalumbo 22 66, Claudia Duran-Aniotz 2 3 Affiliations: 1School, of Psychological Sciences and Health, University of Strathclyde, Glasgow, UK. 2Latin American Institute for Brain Health (BrainLat), Universidad Adolfo Ibanez, Santiago, Chile. 3Center for Social and Cognitive Neuroscience (CSCN), School of Psychology, Universidad Adolfo Ibanez, Santiago, Chile. 4Global Brain Health Institute, Trinity College, Dublin, Ireland. 5Memory and Neuropsychiatric Clinic (CMYN) Neurology Department, Hospital del Salvador y Facultad de Medicina, Universidad de Chile, Santiago, Chile. 6Neuropsychology and Clinical Neuroscience Laboratory (LANNEC), Physiopathology Department - Institute of Biomedical Sciences (ICBM), Neuroscience and East Neuroscience Departments, Faculty of Medicine, Universidad de Chile, Santiago, Chile. 7Unit of Brain Health, Department of Neurology and Neurosurgery, Faculty of Medicine, Universidad de Chile, Santiago, Chile. 8Geroscience Center for Brain Health and Metabolism (GERO), Santiago, Chile. 9Laboratory for Cognitive and Evolutionary Neuroscience (LaNCE), Department of Psychiatry, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile. 10Graduate School, Faculty of Medicine, Universidad Mayor, Chile - Centro de Apoyo Comunitario a Personas con Demencia Kintun, Santiago, Chile. 11Centro Uruguayo de Imagenología Molecular (CUDIM) - Centro de Medicina Nuclear e Imagenología Molecular, Hospital de Clínicas, Universidad de la República, Montevideo, Uruguay. 12Department of Neurology and Psyquiatry, Clínica Alemana-Universidad del Desarrollo, Santiago, Chile. 13Global Brain Health Institute and the Memory and Aging Center, Weill Institute for Neurosciences, Departments of Neurology and Radiology & Biomedical Imaging, University of California, San Francisco (UCSF), San Francisco, California, USA. 14Cognitive Neuroscience Center (CNC), Universidad de San Andrés, & National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentina. 15Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden. 16Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden. 17Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, UK. 18UK Dementia Research Institute at UCL, London, UK. 19Hong Kong Center for Neurodegenerative Diseases, Clear Water Bay, Hong Kong, China. 20Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Amsterdam UMC, Amsterdam, the Netherlands. 21Department of Neurology, Memory and Aging Center, UCSF, San Francisco, California, USA. 22Atlantic Fellow for Equity in Brain Health at the Global Brain Health Institute (GBHI), University of California San Francisco, San Francisco, California, USA. 23HudsonAlpha Institute for Biotechnology, Huntsville, Alabama, USA. 24Medical School, Aging Institute and Psychiatry Department, Neuroscience PhD Program, Pontificia Universidad Javeriana, Bogotá, Colombia. 25Memory and Cognition Center, Intellectus, Hospital Universitario San Ignacio, Bogotá, Colombia. 26Psychiatry Department, Hospital Universitario Santa Fe de Bogotá, Bogotá, Colombia. 27Universidad Nacional Pedro Henriquez Urena (UNPHU), Santo Domingo, República Dominicana. 28Department of Cognitive Neurology, Neuropsychiatry and Neuropsychology, Instituto Neurológico Fleni, Buenos Aires, Argentina. 29Department of Neurosciences, Universidad de la Costa, Barranquilla, Colombia. 30Faculty of Human Medicine, Postgraduate Section, National University of San Marcos, Lima, Perú. 31Mental Health Service, Clínica Universidad de los Andes, Santiago, Chile. 32Department of Psychiatry, Medicine School, Andrés Bello University of Santiago (UNAB), Santiago, Chile. 33Center for Advanced Clinical Research (CICA), Department of Neurology & Neurosurgery and Neuroscience Department, Faculty of Medicine, Universidad de Chile, Santiago, Chile. 34Department of Neurology and Neurosurgery, Hospital Clínico Universidad de Chile, Santiago, Chile. 35Department of Neuroscience, Faculty of Medicine, Universidad de Chile, Santiago, Chile. 36Cognitive and Behavioral Neurology Unit, Department of Neurology, University of São Paulo Medical School, University of São Paulo, São Paulo, Brazil. 37Departamento e Instituto de Psiquiatria, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo HCFMUSP, São Paulo, Brazil. 38Behavioral and Cognitive Neurology Unit, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. 39Instituto Nacional de Ciencias Neurológicas, Lima, Perú. 40Hospital Central de las Fuerzas Armadas, Montevideo, Uruguay. 41Unit of Diagnosis of Cognitive Impairment and Dementia Prevention, Instituto Peruano de Neurociencias, Lima, Perú. 42Department of Neuropsychology, Institut of Neurology, Hospital de Clínicas, Faculty of Medicine, Universidad de la República, Montevideo, Uruguay. 43Cognition and Brain Plasticity Unit, Bellvitge Biomedical Research Institute, Barcelona, Spain. 44Department of Cellular Biology, Physiology and Immunology, Neuroscience Institute, Autonomous University of Barcelona, Barcelona, Spain. 45Department of Internal Medicine, Health Sciences Faculty, Technical University of Ambato, Tungurahua, Ecuador. 46Neurology Service, School of Medicine, Pontifical University of Rio Grande do Sul (PUCRS), Porto Alegre, Brazil. 47Department of Neurology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. 48School of Public Health, Universidad Peruana Cayetano Heredia, Lima, Peru. 49Unit of Cognitive Diseases, Neuromedicenter, Quito, Ecuador. 50Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. 51Unit of Cognitive Evaluation, Department of Geriatry ang Gerentology, Hospital de Clínicas, Faculty of Medicine, Universidad de la República, Montevideo, Uruguay. 52Grupo de Neurociencias de Antioquia, Universidad de Antioquia, School of Medicine, Medellín, Colombia. 53Department of Geriatry ang Gerentology, Hospital Central de la Fuerza Aérea del Perú, Lima, Perú. 54Neurosciences Institute, Favaloro Foundation University Hospital, Buenos Aires, Argentina. 55Group of Neuropsychology and Behavior, Universidad de Antioquia, School of Medicine, Medellín, Colombia. 56Brain Institute of Rio Grande do Sul, Pontifical University of Rio Grande do Sul (PUCRS), Porto Alegre, Brazil. 57Faculdade de Ciências Médicas de Minas Gerais, Belo Horizonte, Brazil. 58Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana Alzheimer's Disease Research Center, Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana, USA. 59Research Group, MI Dneuropsy, Universidad Surcolombiana, Neiva, Colombia. 60Unit of Neuropsychogeriatry, Instituto Nacional de Geriatría, Santiago, Chile. 61Graduate Program in Biomedical Gerontology, Pontifical University of Rio Grande do Sul (PUCRS), Porto Alegre, Brazil. 62FundAlzheimer, Memory Clinic, Cartago, Costa Rica. 63Instituto Nacional de Neurología y Neurocirugía (INNN), Manuel Velasco Suarez, Ciudad de México, México. 64Faculdade Santa Casa BH, Belo Horizonte, Brazil. 65Neuropsychiatry Program, University of Texas Health Science Center at Houston, Houston, Texas, USA. 66Departamento de Neurología, Hospital Universidad Técnica Particular de Loja, Loja, Ecuador. |
| Editorial: | Wiley |
| EN: | Alzheimer's and Dementia. 2023;19:721-735 |
| Citación: | Parra M, Orellana P, Cabello Gonzalez V y otros. Biomarkers for dementia in Latin American countries: Gaps and opportunities. Alzheimer's and Dementia [en línea]. 2023;19:721-735 |
| Cobertura geográfica: | AMÉRICA LATINA |
| Licencia: | Licencia Creative Commons Atribución - No Comercial (CC - By-NC 4.0) |
| Aparece en las colecciones: | Publicaciones Académicas y Científicas - Facultad de Medicina |
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