IAEA research contract Nº: 24022

Abstract

The programme of work to be performed under this Research Project shall be: To • Source funding to support establishment of an animal facility for radio-labeled studies and to train staff on management of radio-labeled depletion studies, sample collection and handling; The next project steps will depend on establishment or identification of the established and supporting facilities; • Conduct radio-labeled Ethion, Fipronil and Chlorpyrifos depletion studies in cattle. Radiolabeled molecules will be needed; • Facilitate preparation of appropriate veterinary drug formulations; • Assess purity of radio-labeled drugs using suitable radiochemical, chromatographic or mass spectrometric detection methods; • Prepare relevant study protocol (s): • Administer radio-labeled compounds in the study food animals and determine total radioactivity by liquid scintillation counter: • Elucidate the structure of the various molecules and their metabolites; • Publish and disseminate research findings.