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Título: | Design and development of 6-hydrazinonicotinylfatty acid-mimetic 99mTc-complex as a potential myocardial imaging agent |
Autor: | González, Joel García, María Fernanda Cabral González, Pablo Calzada, Victoria Cerecetto, Hugo |
Tipo: | Artículo |
Palabras clave: | Technetium, Radiopharmaceutical, Myocardial metabolism, Long chain amide |
Fecha de publicación: | 2024 |
Resumen: | The goal of this work is to identify new fatty acid-mimetic 99mTc-complexes to be used as myocardial imaging agents that allow studying heart abnormalities in high-risk patients. In this sense, we designed a fatty acid-mimetic substructure including an amide moiety that, among other properties, could improve myocardial residence time. A diamide with a chain length of 15 atoms and porting a 6-hydrazinonicotinyl (HYNIC) chelator, and an analog with a short carbon-chain, were prepared with convergent organic synthetic procedures and radiolabeled with 99mTc using tricine as the sole coligand. The in vivo proofs of concept were performed using healthy mice. The new 99mTc-complexes were obtained with adequate radiochemical purity. The lipophilicities were in agreement with the length of the chains. While both 99mTccomplexes showed uptake in the myocardial muscle, the designed radiopharmaceutical with the longest chain length had preferential target-uptake and target-retention compared to other complexes described in the bibliography. Further studies, involving imaging assays, synthetic modifications, and assay of new coligands for 99mTc-HYNIC complexes, are currently ongoing. |
Editorial: | Universidade de São Paulo |
EN: | Brazilian Journal of Pharmaceutical Sciences, 2024, 60: e23542. |
Citación: | González, J, García, M, Cabral González, P [y otros autores]. "Design and development of 6-hydrazinonicotinylfatty acid-mimetic 99mTc-complex as a potential myocardial imaging agent". Brazilian Journal of Pharmaceutical Sciences. [en línea] 2024, 60: e23542. 13 h. DOI: 10.1590/s2175-97902024e23542 |
ISSN: | 2175-9790 |
Licencia: | Licencia Creative Commons Atribución (CC - By 4.0) |
Aparece en las colecciones: | Publicaciones académicas y científicas - Facultad de Ciencias |
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Fichero | Descripción | Tamaño | Formato | ||
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10.1590-s2175-97902024e23542.pdf | 1,04 MB | Adobe PDF | Visualizar/Abrir |
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