Por favor, use este identificador para citar o enlazar este ítem:
https://hdl.handle.net/20.500.12008/43275
Cómo citar
Título: | Oxidative stress in healthy and pathological red blood cells |
Autor: | Orrico, Florencia Laurance, Sandrine López Royes, Ana Clara Lefevre, Sophie D. Thomson, Leonor Möller, Matías N. Ostuni, Mariano A. |
Tipo: | Artículo |
Palabras clave: | Erythrocyte, Reactive oxygen species, Antioxidant, Oxidative stress, Sickle cell disease, Glucose 6-phosphate dehydrogenase deficiency, Pyruvate kinase deficiency |
Fecha de publicación: | 2023 |
Resumen: | Red cell diseases encompass a group of inherited or acquired erythrocyte disorders that affect the structure, function, or production of red blood cells (RBCs). These disorders can lead to various clinical manifestations, including anemia, hemolysis, inflammation, and impaired oxygencarrying capacity. Oxidative stress, characterized by an imbalance between the production of reactive oxygen species (ROS) and the antioxidant defense mechanisms, plays a significant role in the pathophysiology of red cell diseases. In this review, we discuss the most relevant oxidant species involved in RBC damage, the enzymatic and low molecular weight antioxidant systems that protect RBCs against oxidative injury, and finally, the role of oxidative stress in different red cell diseases, including sickle cell disease, glucose 6-phosphate dehydrogenase deficiency, and pyruvate kinase deficiency, highlighting the underlying mechanisms leading to pathological RBC phenotypes. |
Editorial: | MDPI |
EN: | Biomolecules, 2023, 13(8): 1262. |
Financiadores: | CSIC: I+D_2020_557 |
Citación: | Orrico, F, Laurance, S, López Royes, A [y otros autores]. "Oxidative stress in healthy and pathological red blood cells". Biomolecules. [en línea] 2023, 13(8): 1262. 20 h. DOI: 10.3390/biom13081262. |
ISSN: | 2218-273X |
Aparece en las colecciones: | Publicaciones académicas y científicas - Facultad de Ciencias |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | ||
---|---|---|---|---|---|
10.3390.biom13081262.pdf | 1,42 MB | Adobe PDF | Visualizar/Abrir |
Este ítem está sujeto a una licencia Creative Commons Licencia Creative Commons