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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Barrios, Anabella | - |
dc.contributor.author | Mouhape, Camila | - |
dc.contributor.author | Schreiber, Leonard | - |
dc.contributor.author | Zhang, Linyun | - |
dc.contributor.author | Nell, Juliane | - |
dc.contributor.author | Suárez Martins, Mariana Carolina | - |
dc.contributor.author | Schlapp, Geraldine | - |
dc.contributor.author | Meikle, María Noel | - |
dc.contributor.author | Mulet, Ana Paula | - |
dc.contributor.author | Hsu, Tsui-Ling | - |
dc.contributor.author | Hsieh, Shie-Liang | - |
dc.contributor.author | Mourglia-Ettlin, Gustavo | - |
dc.contributor.author | González, Carlos | - |
dc.contributor.author | Crispo, Martina | - |
dc.contributor.author | Barth, Thomas F. E. | - |
dc.contributor.author | Casaravilla, Cecilia | - |
dc.contributor.author | Jenkins, Stephen J. | - |
dc.contributor.author | Díaz, Álvaro | - |
dc.date.accessioned | 2024-03-01T14:30:16Z | - |
dc.date.available | 2024-03-01T14:30:16Z | - |
dc.date.issued | 2023 | - |
dc.identifier.citation | Barrios, A, Mouhape, C, Schreiber, L [y otros autores]. "Mucins shed from the laminated layer in cystic Echinococcosis are aaptured by Kupffer cells via the Lectin receptor Clec4F". Infection and Immunity. [en línea] 2023, 91(6): e00031-23. 19 h. DOI: 10.1128/iai.00031-23. | es |
dc.identifier.issn | 1098-5522 | - |
dc.identifier.uri | https://hdl.handle.net/20.500.12008/42836 | - |
dc.description.abstract | Cystic echinococcosis is caused by the larval stages (hydatids) of cestode parasites belonging to the species cluster Echinococcus granulosus sensu lato, with E. granulosus sensu stricto being the main infecting species. Hydatids are bladderlike structures that attain large sizes within various internal organs of livestock ungulates and humans. Hydatids are protected by the massive acellular laminated layer (LL), composed mainly of mucins. Parasite growth requires LL turnover, and abundant LL-derived particles are found at infection sites in infected humans, raising the question of how LL materials are dealt with by the hosts. In this article, we show that E. granulosus sensu stricto LL mucins injected into mice are taken up by Kupffer cells, the liver macrophages exposed to the vascular space. This uptake is largely dependent on the intact mucin glycans and on Clec4F, a C-type lectin receptor which, in rodents, is selectively expressed in Kupffer cells. This uptake mechanism operates on mucins injected both in soluble form intravenously (i.v.) and in particulate form intraperitoneally (i.p.). In mice harboring intraperitoneal infections by the same species, LL mucins were found essentially only at the infection site and in the liver, where they were taken up by Kupffer cells via Clec4F. Therefore, shed LL materials circulate in the host, and Kupffer cells can act as a sink for these materials, even when the parasite grows in sites other than the liver. | es |
dc.description.sponsorship | ANII: FCE_ 136130 | es |
dc.description.sponsorship | CSIC: I+D_558 | es |
dc.format.extent | 19 h. | es |
dc.format.mimetype | application/pdf | es |
dc.language.iso | en | es |
dc.publisher | American Society of Microbiology | es |
dc.relation.ispartof | Infection and Immunity, 2023, 91(6): e00031-23. | es |
dc.rights | Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014) | es |
dc.subject | Echinococcus | es |
dc.subject | Laminated layer | es |
dc.subject | Lectin | es |
dc.subject | Mucin | es |
dc.subject | Kupffer cells | es |
dc.subject | Clec4F | es |
dc.title | Mucins shed from the laminated layer in cystic Echinococcosis are aaptured by Kupffer cells via the Lectin receptor Clec4F | es |
dc.type | Artículo | es |
dc.contributor.filiacion | Barrios Anabella, Universidad de la República (Uruguay). Facultad de Química. | - |
dc.contributor.filiacion | Mouhape Camila, Universidad de la República (Uruguay). Facultad de Química. | - |
dc.contributor.filiacion | Schreiber Leonard | - |
dc.contributor.filiacion | Zhang Linyun | - |
dc.contributor.filiacion | Nell Juliane | - |
dc.contributor.filiacion | Suárez Martins Mariana Carolina, Universidad de la República (Uruguay). Facultad de Química. | - |
dc.contributor.filiacion | Schlapp Geraldine, Instituto Pasteur (Montevideo). | - |
dc.contributor.filiacion | Meikle María Noel, Instituto Pasteur (Montevideo). | - |
dc.contributor.filiacion | Mulet Ana Paula, Instituto Pasteur (Montevideo). | - |
dc.contributor.filiacion | Hsu Tsui-Ling | - |
dc.contributor.filiacion | Hsieh Shie-Liang | - |
dc.contributor.filiacion | Mourglia-Ettlin Gustavo, Universidad de la República (Uruguay). Facultad de Química. | - |
dc.contributor.filiacion | González Carlos | - |
dc.contributor.filiacion | Crispo Martina, Instituto Pasteur (Montevideo). | - |
dc.contributor.filiacion | Barth Thomas F. E. | - |
dc.contributor.filiacion | Casaravilla Cecilia, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Química Biológica. | - |
dc.contributor.filiacion | Jenkins Stephen J. | - |
dc.contributor.filiacion | Díaz Álvaro, Universidad de la República (Uruguay). Facultad de Química. | - |
dc.rights.licence | Licencia Creative Commons Atribución - No Comercial - Compartir Igual (CC - By-NC-SA 4.0) | es |
dc.identifier.doi | 10.1128/iai.00031-23 | - |
Aparece en las colecciones: | Publicaciones académicas y científicas - Facultad de Ciencias |
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