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Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12008/41412 How to cite
Title: Current status of regulatory non-coding RNAs research in the tritryp
Authors: Fort Canobra, Rafael S
Chávez, Santiago
Trinidad Barnech, Juan Manuel
Oliveira-Rizzo, Carolina
Smircich, Pablo
Sotelo Silveira, José Roberto
Duhagon, María Ana
Type: Artículo
Keywords: Trypanosomatids, Tritryp, Trypanosoma, Leishmania, non-coding RNA, ncRNA, tRNA, snoRNA, snRNA, siRNA
Issue Date: 2022
Abstract: Trypanosomatids are protozoan parasites that cause devastating vector-borne human diseases. Gene expression regulation of these organisms depends on post-transcriptional control in responding to diverse environments while going through multiple developmental stages of their complex life cycles. In this scenario, non-coding RNAs (ncRNAs) are excellent candidates for a very efficient, quick, and economic strategy to regulate gene expression. The advent of high throughput RNA sequencing technologies show the presence and deregulation of small RNA fragments derived from canonical ncRNAs. This review seeks to depict the ncRNA landscape in trypanosomatids, focusing on the small RNA fragments derived from functional RNA molecules observed in RNA sequencing studies. Small RNA fragments derived from canonical ncRNAs (tsRNAs, snsRNAs, sdRNAs, and sdrRNAs) were identified in trypanosomatids. Some of these RNAs display changes in their levels associated with different environments and developmental stages, demanding further studies to determine their functional characterization and potential roles. Nevertheless, a comprehensive and detailed ncRNA annotation for most trypanosomatid genomes is still needed, allowing better and more extensive comparative and functional studies.
Publisher: MDPI
IN: Non-Coding RNA, 2022, 8(4): 54.
Sponsors: CSIC: I+D 2020_566
DOI: 10.3390/ncrna8040054
ISSN: 2311-553X
Citation: Fort Canobra, R, Chávez, S, Trinidad Barnech, J. , y otros. "Current status of regulatory non-coding RNAs research in the tritryp". Non-Coding RNA. [en línea] 2022, 8(4): 54. 22 h. DOI: 10.3390/ncrna8040054
License: Licencia Creative Commons Atribución (CC - By 4.0)
Appears in Collections:Publicaciones académicas y científicas - Facultad de Ciencias

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