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DC Field | Value | Language |
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dc.contributor.author | Oliveira-Rizzo, Carolina | - |
dc.contributor.author | Ottati Braselli, María Carolina | - |
dc.contributor.author | Fort Canobra, Rafael S | - |
dc.contributor.author | Chávez, Santiago | - |
dc.contributor.author | Trinidad Barnech, Juan Manuel | - |
dc.contributor.author | Di Paolo, Andrés | - |
dc.contributor.author | Garat, Beatriz | - |
dc.contributor.author | Sotelo Silveira, José Roberto | - |
dc.contributor.author | Duhagon, María Ana | - |
dc.date.accessioned | 2023-11-21T14:36:02Z | - |
dc.date.available | 2023-11-21T14:36:02Z | - |
dc.date.issued | 2022 | - |
dc.identifier.citation | Oliveira-Rizzo, C, Ottati Braselli, M, Fort Canobra, R. y otros. "Hsa-miR-183-5p modulates cell adhesion by repression of ITGB1 expression in prostate cancer". Non-Coding RNA. [en línea] 2022, 8(1): 11.21 h. DOI: 10.3390/ncrna8010011 | es |
dc.identifier.issn | 2311-553X | - |
dc.identifier.uri | https://hdl.handle.net/20.500.12008/41376 | - |
dc.description.abstract | Prostate cancer is a major health problem worldwide. MiR-183 is an oncomiR and a candidate biomarker in prostate cancer, affecting various pathways responsible for disease initiation and progression. We sought to discover the most relevant processes controlled by miR-183 through an unbiased transcriptomic approach using prostate cell lines and patient tissues to identify miR-183 responsive genes and pathways. Gain of unction experiments, reporter gene assays, and transcript and protein measurements were conducted to validate predicted functional effects and protein mediators. A total of 135 candidate miR-183 target genes overrepresenting cell adhesion terms were inferred from the integrated transcriptomic analysis. Cell attachment, spreading assays and focal adhesion quantification of miR-183-overexpressing cells confirmed the predicted reduction in cell adhesion. ITGB1 was validated as a major target of repression by miR-183 as well as a mediator of cell adhesion in response to miR-183. The reporter gene assay and PAR-CLIP read mapping suggest that ITGB1 may be a direct target of miR-183. The negative correlation between miR-183 and ITGB1 expression in prostate cancer cohorts supports their interaction in the clinical set. Overall, cell adhesion was uncovered as a major pathway controlled by miR-183 in prostate cancer, and ITGB1 was identified as a relevant mediator of this effect. | es |
dc.description.sponsorship | CSIC: I+D 2016_487 | es |
dc.description.sponsorship | CSIC: I+D 2020_566 | es |
dc.format.extent | 21 h. | es |
dc.format.mimetype | application/pdf | es |
dc.language.iso | en_US | es |
dc.publisher | MDPI | es |
dc.relation.ispartof | Non-Coding RNA, 2022, 8(1): 11. | es |
dc.rights | Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014) | es |
dc.subject | Cancer | es |
dc.subject | MicroRNA | es |
dc.subject | Focal adhesion | es |
dc.subject | miR-183 | es |
dc.subject | Prostate | es |
dc.subject | ITGB | es |
dc.subject | TCGA | es |
dc.subject | AGO-PAR-CLIP | es |
dc.title | Hsa-miR-183-5p modulates cell adhesion by repression of ITGB1 expression in prostate cancer | es |
dc.type | Artículo | es |
dc.contributor.filiacion | Oliveira-Rizzo Carolina, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Química Biológica. | - |
dc.contributor.filiacion | Ottati Braselli María Carolina, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Química Biológica. | - |
dc.contributor.filiacion | Fort Canobra Rafael S, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Química Biológica. | - |
dc.contributor.filiacion | Chávez Santiago, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Química Biológica. | - |
dc.contributor.filiacion | Trinidad Barnech Juan Manuel, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Química Biológica. | - |
dc.contributor.filiacion | Di Paolo Andrés, IIBCE | - |
dc.contributor.filiacion | Garat Beatriz, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Química Biológica. | - |
dc.contributor.filiacion | Sotelo Silveira José Roberto, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología. | - |
dc.contributor.filiacion | Duhagon María Ana, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Química Biológica. | - |
dc.rights.licence | Licencia Creative Commons Atribución (CC - By 4.0) | es |
dc.identifier.doi | 10.3390/ncrna8010011 | - |
Appears in Collections: | Publicaciones académicas y científicas - Facultad de Ciencias |
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File | Description | Size | Format | ||
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103390ncrna8010011.pdf | 2,11 MB | Adobe PDF | View/Open |
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