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Title: | Emergence and spread of a B.1.1.28-derived P.6 lineage with Q675H and Q677H spike mutations in Uruguay |
Authors: | Rego, Natalia Salazar González, María Cecilia Paz, Mercedes Costábile Cristech, Alicia Fajardo Rossi, Álvaro Ferrés Cáceres, Ignacio Perbolianachis Duarte, Paula Fernández Calero, Tamara Veronica, Noya Machado, Matías Brandes Lamas, Mariana Sofía Arce Rama, Rodrigo Arleo Capovilla, Mailén Possi, Tania Reyes, Natalia Bentancor, María Noel Lizasoaín Cuelho, Andrés Bortagaray Galluzzo, Viviana Moller, Ana Chappos, Odhille Nin, Nicolás Hurtado, Francisco Javier Duquía, Melissa González, María Belén Griffero Ramilo, Luciana Méndez, Mauricio Techera, María Pía Smircich, Pablo Mir, Daiana Alonso, Cecilia Medina, Julio Albornoz, Henry Colina, Rodney Bello, Gonzalo Moreno Karlen, María del Pilar Moratorio, Gonzalo Iraola, Gregorio Spangenberg, Lucía |
Type: | Artículo |
Keywords: | SARS-CoV-2, B.1.1.28, Spike, Q675H, Q677H, Phylogeography, Phylogenetics |
Issue Date: | 2021 |
Abstract: | Uruguay controlled the viral dissemination during the first nine months of the SARS-CoV-2 pandemic. Unfortunately, towards the end of 2020, the number of daily new cases exponentially increased. Herein, we analyzed the country-wide genetic diversity of SARS-CoV-2 between November 2020 and April 2021. We identified that the most prevalent viral variant during the first epidemic wave in Uruguay (December 2020–February 2021) was a B.1.1.28 sublineage carrying Spike mutations Q675H + Q677H, now designated as P.6, followed by lineages P.2 and P.7. P.6 probably arose around November 2020, in Montevideo, Uruguay’s capital department, and rapidly spread to other departments, with evidence of further local transmission clusters; it also spread sporadically to the USA and Spain. The more efficient dissemination of lineage P.6 with respect to P.2 and P.7 and the presence of mutations (Q675H and Q677H) in the proximity of the key cleavage site at the S1/S2 boundary suggest that P.6 may be more transmissible than other lineages co-circulating in Uruguay. Although P.6 was replaced by the variant of concern (VOC) P.1 as the predominant lineage in Uruguay since April 2021, the monitoring of the concurrent emergence of Q675H + Q677H in VOCs should be of worldwide interest. |
Publisher: | MDPI |
IN: | Viruses, 2021, 13(9): 1801. |
Citation: | Rego, N, Salazar González, M, Paz, M [y otros autores]. "Emergence and spread of a B.1.1.28-derived P.6 lineage with Q675H and Q677H spike mutations in Uruguay". Viruses. [en línea] 2021, 13(9): 1801. 16 h. DOI: 10.3390/v13091801. |
ISSN: | 1999-4915 |
Geographic coverage: | Uruguay |
Appears in Collections: | Publicaciones académicas y científicas - Facultad de Ciencias |
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File | Description | Size | Format | ||
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103390v13091801.pdf | 1,73 MB | Adobe PDF | View/Open |
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