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Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12008/41299 How to cite
Title: Emergence and spread of a B.1.1.28-derived P.6 lineage with Q675H and Q677H spike mutations in Uruguay
Authors: Rego, Natalia
Salazar González, María Cecilia
Paz, Mercedes
Costábile Cristech, Alicia
Fajardo Rossi, Álvaro
Ferrés Cáceres, Ignacio
Perbolianachis Duarte, Paula
Fernández Calero, Tamara
Veronica, Noya
Machado, Matías
Brandes Lamas, Mariana Sofía
Arce Rama, Rodrigo
Arleo Capovilla, Mailén
Possi, Tania
Reyes, Natalia
Bentancor, María Noel
Lizasoaín Cuelho, Andrés
Bortagaray Galluzzo, Viviana
Moller, Ana
Chappos, Odhille
Nin, Nicolás
Hurtado, Francisco Javier
Duquía, Melissa
González, María Belén
Griffero Ramilo, Luciana
Méndez, Mauricio
Techera, María Pía
Smircich, Pablo
Mir, Daiana
Alonso, Cecilia
Medina, Julio
Albornoz, Henry
Colina, Rodney
Bello, Gonzalo
Moreno Karlen, María del Pilar
Moratorio, Gonzalo
Iraola, Gregorio
Spangenberg, Lucía
Type: Artículo
Keywords: SARS-CoV-2, B.1.1.28, Spike, Q675H, Q677H, Phylogeography, Phylogenetics
Issue Date: 2021
Abstract: Uruguay controlled the viral dissemination during the first nine months of the SARS-CoV-2 pandemic. Unfortunately, towards the end of 2020, the number of daily new cases exponentially increased. Herein, we analyzed the country-wide genetic diversity of SARS-CoV-2 between November 2020 and April 2021. We identified that the most prevalent viral variant during the first epidemic wave in Uruguay (December 2020–February 2021) was a B.1.1.28 sublineage carrying Spike mutations Q675H + Q677H, now designated as P.6, followed by lineages P.2 and P.7. P.6 probably arose around November 2020, in Montevideo, Uruguay’s capital department, and rapidly spread to other departments, with evidence of further local transmission clusters; it also spread sporadically to the USA and Spain. The more efficient dissemination of lineage P.6 with respect to P.2 and P.7 and the presence of mutations (Q675H and Q677H) in the proximity of the key cleavage site at the S1/S2 boundary suggest that P.6 may be more transmissible than other lineages co-circulating in Uruguay. Although P.6 was replaced by the variant of concern (VOC) P.1 as the predominant lineage in Uruguay since April 2021, the monitoring of the concurrent emergence of Q675H + Q677H in VOCs should be of worldwide interest.
Publisher: MDPI
IN: Viruses, 2021, 13(9): 1801.
Citation: Rego, N, Salazar González, M, Paz, M [y otros autores]. "Emergence and spread of a B.1.1.28-derived P.6 lineage with Q675H and Q677H spike mutations in Uruguay". Viruses. [en línea] 2021, 13(9): 1801. 16 h. DOI: 10.3390/v13091801.
ISSN: 1999-4915
Geographic coverage: Uruguay
Appears in Collections:Publicaciones académicas y científicas - Facultad de Ciencias

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