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Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12008/40941 How to cite
Title: Altering compositional properties of viral genomes to design Llve-attenuated vaccines
Authors: Pereira Gómez, Marianoel
Carrau Eguía, Lucía
Fajardo Rossi, Álvaro
Moreno Karlen, María del Pilar
Moratorio, Gonzalo
Type: Artículo
Keywords: RNA viruses, Genome composition, Codon usage, Codon pair bias, Mutational robustness, Attenuation, vaccines
Issue Date: 2021
Abstract: Live-attenuated vaccines have been historically used to successfully prevent numerous diseases caused by a broad variety of RNA viruses due to their ability to elicit strong and perdurable immune-protective responses. In recent years, various strategies have been explored to achieve viral attenuation by rational genetic design rather than using classic and empirical approaches, based on successive passages in cell culture. A deeper understanding of evolutionary implications of distinct viral genomic compositional aspects, as well as substantial advances in synthetic biology technologies, have provided a framework to achieve new viral attenuation strategies. Herein, we will discuss different approaches that are currently applied to modify compositional features of viruses in order to develop novel live-attenuated vaccines.
Publisher: Frontiers
IN: Frontiers in Microbiology, 2021, 12: 676582.
Sponsors: ANII: FCE_1_2019_1_156157
ANII: FCE_1_2019_1_155930
Citation: Pereira Gómez, M, Carrau, L, Fajardo Rossi, Á, [y otros autores]. "Altering compositional properties of viral genomes to design live-attenuated vaccines". Frontiers in Microbiology. [en línea] 2021, 12: 676582. 8 h. DOI: 10.3389/fmicb.2021.676582.
ISSN: 1664-302X
Appears in Collections:Publicaciones académicas y científicas - Facultad de Ciencias

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