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Title: | Altering compositional properties of viral genomes to design Llve-attenuated vaccines |
Authors: | Pereira Gómez, Marianoel Carrau Eguía, Lucía Fajardo Rossi, Álvaro Moreno Karlen, María del Pilar Moratorio, Gonzalo |
Type: | Artículo |
Keywords: | RNA viruses, Genome composition, Codon usage, Codon pair bias, Mutational robustness, Attenuation, vaccines |
Issue Date: | 2021 |
Abstract: | Live-attenuated vaccines have been historically used to successfully prevent numerous diseases caused by a broad variety of RNA viruses due to their ability to elicit strong and perdurable immune-protective responses. In recent years, various strategies have been explored to achieve viral attenuation by rational genetic design rather than using classic and empirical approaches, based on successive passages in cell culture. A deeper understanding of evolutionary implications of distinct viral genomic compositional aspects, as well as substantial advances in synthetic biology technologies, have provided a framework to achieve new viral attenuation strategies. Herein, we will discuss different approaches that are currently applied to modify compositional features of viruses in order to develop novel live-attenuated vaccines. |
Publisher: | Frontiers |
IN: | Frontiers in Microbiology, 2021, 12: 676582. |
Sponsors: | ANII: FCE_1_2019_1_156157 ANII: FCE_1_2019_1_155930 |
Citation: | Pereira Gómez, M, Carrau, L, Fajardo Rossi, Á, [y otros autores]. "Altering compositional properties of viral genomes to design live-attenuated vaccines". Frontiers in Microbiology. [en línea] 2021, 12: 676582. 8 h. DOI: 10.3389/fmicb.2021.676582. |
ISSN: | 1664-302X |
Appears in Collections: | Publicaciones académicas y científicas - Facultad de Ciencias |
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