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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Olivera Bravo, Silvia | - |
dc.contributor.author | Bolatto Pereira, Carmen Isabel Selene | - |
dc.contributor.author | Otero Damianovich, Nicolás Gabriel | - |
dc.contributor.author | Stancov Iturrioz, Matías | - |
dc.contributor.author | Cerri Fassio, Sofía Natalia | - |
dc.contributor.author | Rodríguez, Paola | - |
dc.contributor.author | Boragno, Daniela | - |
dc.contributor.author | Cuitiño, María Noel | - |
dc.contributor.author | Larrambembere, Fernanda | - |
dc.contributor.author | Isasi, Eugenia | - |
dc.contributor.author | Marco, Marta | - |
dc.contributor.author | Alem, Diego | - |
dc.contributor.author | Canclini, Lucía | - |
dc.contributor.author | Hernandéz Mir, karina | - |
dc.contributor.author | Davyt, Danilo | - |
dc.date.accessioned | 2023-08-09T15:09:46Z | - |
dc.date.available | 2023-08-09T15:09:46Z | - |
dc.date.issued | 2022 | - |
dc.identifier.citation | Olivera Bravo, S, Bolatto Pereira, C, Otero Damianovich, N, [y otros autores]. "Neuroprotective effects of violacein in a model of inherited amyotrophic lateral sclerosis". Scientific Reports. [en línea] 2022, 12:4439. 19 h. DOI: 10.1038/s41598-022-06470-7 | es |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://hdl.handle.net/20.500.12008/39131 | - |
dc.description.abstract | Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive death of motor neurons and muscle atrophy, with defective neuron-glia interplay and emergence of aberrant glial phenotypes having a role in disease pathology. Here, we have studied if the pigment violacein with several reported protective/antiproliferative properties may control highly neurotoxic astrocytes (AbAs) obtained from spinal cord cultures of symptomatic hSOD1G93A rats, and if it could be neuroprotective in this ALS experimental model. At concentrations lower than those reported as protective, violacein selectively killed aberrant astrocytes. Treatment of hSOD1G93A rats with doses equivalent to the concentrations that killed AbAs caused a marginally significant delay in survival, partially preserved the body weight and soleus muscle mass and improved the integrity of the neuromuscular junction. Reduced motor neuron death and glial reactivity was also found and likely related to decreased inflammation and matrix metalloproteinase-2 and -9. Thus, in spite that new experimental designs aimed at extending the lifespan of hSOD1G93A rats are needed, improvements observed upon violacein treatment suggest a significant therapeutic potential that deserves further studies. | es |
dc.description.sponsorship | IIBCE (MEC), PEDECIBA y ANII. | es |
dc.format.extent | 19 h. | es |
dc.format.mimetype | application/pdf | es |
dc.language.iso | en_US | es |
dc.publisher | Springer Nature | es |
dc.relation.ispartof | Scientific Reports, 2022, 12: 4439. | es |
dc.rights | Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014) | es |
dc.subject | Cell biology | es |
dc.subject | Neuroscience | es |
dc.title | Neuroprotective effects of violacein in a model of inherited amyotrophic lateral sclerosis | es |
dc.type | Artículo | es |
dc.contributor.filiacion | Olivera Bravo Silvia, Instituto Pasteur (Montevideo). | - |
dc.contributor.filiacion | Bolatto Pereira Carmen Isabel Selene, Instituto Pasteur (Montevideo). | - |
dc.contributor.filiacion | Otero Damianovich Nicolás Gabriel, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología. | - |
dc.contributor.filiacion | Stancov Iturrioz Matías, Instituto Pasteur (Montevideo). | - |
dc.contributor.filiacion | Cerri Fassio Sofía Natalia, Instituto Pasteur (Montevideo). | - |
dc.contributor.filiacion | Rodríguez Paola, Instituto Pasteur (Montevideo). | - |
dc.contributor.filiacion | Boragno Daniela, Instituto Pasteur (Montevideo). | - |
dc.contributor.filiacion | Cuitiño María Noel, Instituto Pasteur (Montevideo). | - |
dc.contributor.filiacion | Larrambembere Fernanda, Instituto Pasteur (Montevideo). | - |
dc.contributor.filiacion | Isasi Eugenia, Instituto Pasteur (Montevideo). | - |
dc.contributor.filiacion | Marco Marta, Instituto Pasteur (Montevideo). | - |
dc.contributor.filiacion | Alem Diego, Instituto Pasteur (Montevideo). | - |
dc.contributor.filiacion | Canclini Lucía, Instituto Pasteur (Montevideo). | - |
dc.contributor.filiacion | Hernandéz Mir karina, Universidad de la República (Uruguay). Facultad de Medicina. | - |
dc.contributor.filiacion | Davyt Danilo, Universidad de la República (Uruguay). Facultad de Química. | - |
dc.rights.licence | Licencia Creative Commons Atribución - No Comercial - Compartir Igual (CC - By-NC-SA 4.0) | es |
dc.identifier.doi | 10.1038/s41598-022-06470-7 | - |
Aparece en las colecciones: | Publicaciones académicas y científicas - Facultad de Ciencias |
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101038s41598022064707.pdf | 10,14 MB | Adobe PDF | Visualizar/Abrir |
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