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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Paz, Mercedes | - |
dc.contributor.author | Aldunate Caramori, Fabián | - |
dc.contributor.author | Arce Rama, Rodrigo | - |
dc.contributor.author | Ferreiro Fernández, Irene | - |
dc.contributor.author | Cristina, Juan | - |
dc.date.accessioned | 2023-08-09T12:06:20Z | - |
dc.date.available | 2023-08-09T12:06:20Z | - |
dc.date.issued | 2022 | - |
dc.identifier.citation | Paz, M, Aldunate Caramori, F, Arce Rama, R, [y otros autores]. "An evolutionary insight into Severe Acute Respiratory Syndrome Coronavirus 2 Omicron variant of concern" [Preprint] 2022. 6 h. | es |
dc.identifier.uri | https://hdl.handle.net/20.500.12008/39114 | - |
dc.description | Publicado en: Virus Research, 2022, 314: 198753. DOI: 10.1016/j.virusres.2022.198753 | es |
dc.description.abstract | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel virus that belongs to the family Coronaviridae. This virus produces a respiratory illness known as coronavirus disease 2019 (COVID-19) and is to blame for the pandemic of COVID-19. Due to its massive circulation around the world and the capacity of mutation of this virus, genomic studies are much needed in to order to reveal new variants of concern (VOCs). On November 26th, 2021, the WHO announced that a new SARS-CoV-2 VOC, named Omicron, had emerged. In order to get insight into the emergence, spread and evolution of Omicron SARS-CoV-2 variants, a comprehensive phylogenetic study was performed. The results of these studies revealed significant differences in codon usage among the S genes of SARS-CoV-2 VOCs Alfa, Beta, Gamma, Delta and Omicron, which can be linked to SARS CoV-2 genotypes. Omicron variant did not evolve out of one of the early VOCs, but instead it belongs to a complete different genetic lineage from previous ones. Strains classified as Omicron variants evolved from ancestors that existed around May 15th, 2020, suggesting that this VOC may have been circulating undetected for a period of time until its emergence was observed in South Africa. A rate of evolution of 5.61 × 10 4 substitutions/site/year was found for Omicron strains enrolled in these analyses. The results of these studies demonstrate that S genes have suitable genetic information for clear assignment of emerging VOCs to its specific genotypes. | es |
dc.description.sponsorship | Agencia Nacional de Investigación e Innovación y PEDECIBA, Uruguay. | es |
dc.format.extent | 6 h. | es |
dc.format.mimetype | application/pdf | es |
dc.language.iso | en_US | es |
dc.rights | Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014) | es |
dc.subject | Coronavirus | es |
dc.subject | Evolution | es |
dc.subject | SARS-CoV-2 | es |
dc.subject | Omicron | es |
dc.subject | COVID-19 | es |
dc.title | An evolutionary insight into Severe Acute Respiratory Syndrome Coronavirus 2 Omicron variant of concern | es |
dc.type | Preprint | es |
dc.contributor.filiacion | Paz Mercedes, Universidad de la República (Uruguay). Facultad de Ciencias. Centro de Investigaciones Nucleares. | - |
dc.contributor.filiacion | Aldunate Caramori Fabián, Universidad de la República (Uruguay). Facultad de Ciencias. Centro de Investigaciones Nucleares. | - |
dc.contributor.filiacion | Arce Rama Rodrigo, Universidad de la República (Uruguay). Facultad de Ciencias. Centro de Investigaciones Nucleares. | - |
dc.contributor.filiacion | Ferreiro Fernández Irene, Universidad de la República (Uruguay). Facultad de Ciencias. Centro de Investigaciones Nucleares. | - |
dc.contributor.filiacion | Cristina Juan, Universidad de la República (Uruguay). Facultad de Ciencias. Centro de Investigaciones Nucleares. | - |
dc.rights.licence | Licencia Creative Commons Atribución - No Comercial - Sin Derivadas (CC - By-NC-ND 4.0) | es |
Aparece en las colecciones: | Publicaciones académicas y científicas - Facultad de Ciencias |
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