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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Berrosteguieta Rodríguez, Inés | - |
dc.contributor.author | Rosillo Martí, Juan Carlos | - |
dc.contributor.author | Herrera, María Laura | - |
dc.contributor.author | Olivera-Bravo, Silvia | - |
dc.contributor.author | Casanova, Gabriela | - |
dc.contributor.author | Herránz-Pérez, Vicente | - |
dc.contributor.author | García-Verdugo, José Manuel | - |
dc.contributor.author | Fernández Constenla, Anabel Sonia | - |
dc.date.accessioned | 2023-07-21T17:13:24Z | - |
dc.date.available | 2023-07-21T17:13:24Z | - |
dc.date.issued | 2022 | - |
dc.identifier.citation | Berrosteguieta Rodríguez, I, Rosillo Martí, J, Herrera, M, [y otros autores]. "Plasticity of cell proliferation in the retina of Austrolebias charrua fish under light and darkness conditions". Current Research in Neurobiology. [en línea] 2022, 3, 100042.16 h. DOI:10.1016/j.crneur.2022.100042 | es |
dc.identifier.issn | 2665-945X | - |
dc.identifier.uri | https://hdl.handle.net/20.500.12008/38333 | - |
dc.description.abstract | Austrolebias annual fishes exhibit cell proliferation and neurogenesis throughout life. They withstand extreme environmental changes as their habitat dries out, pressuring nervous system to adapt. Their visual system is challenged to adjust as the water becomes turbid. Therefore, this study focused on how change in photic environment can lead to an increased cell proliferation in the retina. We administered 5-chloro-2′ - deoxyuridine (CldU) and 5-iodo-2′ -deoxyuridine (IdU) at different temporal windows to detect cell proliferation in natural light and permanent darkness. Stem/progenitor cells were recognized as IdU+/CldU + nuclei co-labeled with Sox2, Pax6 or BLBP found in the ciliary marginal zone (CMZ). The expression pattern of BLBP + glial cells and ultrastructural analysis indicates that CMZ has different cell progenitors. In darkness, the number of dividing cells significantly increased, compared to light conditions. Surprisingly, CMZ IdU+/CldU + cell number was similar under light and darkness, suggesting a stable pool of stem/progenitor cells possibly responsible for retinal growth. Therefore, darkness stimulated cell progenitors outside the CMZ, where Müller glia play a crucial role to generate rod precursors and other cell types that might integrate rod-dependent circuits to allow darkness adaptation. Thus, the Austrolebias fish retina shows great plasticity, with cell proliferation rates significantly higher than that of brain visual areas. | es |
dc.format.extent | 16 h. | es |
dc.format.mimetype | application/pdf | es |
dc.language.iso | en_US | es |
dc.publisher | Elsevier B.V. | es |
dc.relation.ispartof | Current Research in Neurobiology, 2022, 3: 100042. | es |
dc.rights | Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014) | es |
dc.subject | Stem cell | es |
dc.subject | Fish brain | es |
dc.subject | Rods | es |
dc.subject | Ciliary marginal zone | es |
dc.title | Plasticity of cell proliferation in the retina of Austrolebias charrua fish under light and darkness conditions | es |
dc.type | Artículo | es |
dc.contributor.filiacion | Berrosteguieta Rodríguez Inés, IIBCE | - |
dc.contributor.filiacion | Rosillo Martí Juan Carlos, IIBCE | - |
dc.contributor.filiacion | Herrera María Laura, IIBCE | - |
dc.contributor.filiacion | Olivera-Bravo Silvia, IIBCE | - |
dc.contributor.filiacion | Casanova Gabriela, Universidad de la República (Uruguay). Facultad de Ciencias. Unidad de Microscopía. | - |
dc.contributor.filiacion | Herránz-Pérez Vicente | - |
dc.contributor.filiacion | García-Verdugo José Manuel | - |
dc.contributor.filiacion | Fernández Constenla Anabel Sonia, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología. | - |
dc.rights.licence | Licencia Creative Commons Atribución - No Comercial - Sin Derivadas (CC - By-NC-ND 4.0) | es |
dc.identifier.doi | 10.1016/j.crneur.2022.100042 | - |
Aparece en las colecciones: | Publicaciones académicas y científicas - Facultad de Ciencias |
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101016jcrneur2022100042.pdf | 13,71 MB | Adobe PDF | Visualizar/Abrir |
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