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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Anzibar Fialho, Maximiliano | - |
dc.contributor.author | Vázquez Alberdi, Lucía | - |
dc.contributor.author | Martínez, Mariana | - |
dc.contributor.author | Calero, Miguel | - |
dc.contributor.author | Baranger, Jerome | - |
dc.contributor.author | Tanter, Mickael | - |
dc.contributor.author | Damián, Juan Pablo | - |
dc.contributor.author | Negreira, Carlos | - |
dc.contributor.author | Rubido, Nicolás | - |
dc.contributor.author | Kun González, Alejandra E. | - |
dc.contributor.author | Brum, Javier | - |
dc.date.accessioned | 2023-07-21T16:16:56Z | - |
dc.date.available | 2023-07-21T16:16:56Z | - |
dc.date.issued | 2022 | - |
dc.identifier.citation | Anzibar Fialho, M, Vázquez Alberdi, L, Martínez, M, [y otros autores]. "Intensity distribution segmentation in ultrafast Doppler combined with scanning laser confocal microscopy for assessing vascular changes associated with ageing in murine hippocampi". Scientific Reports. [en línea] 2022, 12(1):6784.10 h. DOI: 10.1038/s41598-022-10457-9 | es |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://hdl.handle.net/20.500.12008/38319 | - |
dc.description.abstract | The hippocampus plays an important role in learning and memory, requiring high-neuronal oxygenation. Understanding the relationship between blood flow and vascular structure—and how it changes with ageing—is physiologically and anatomically relevant. Ultrafast Doppler ( μDoppler) and scanning laser confocal microscopy (SLCM) are powerful imaging modalities that can measure in vivo cerebral blood volume (CBV) and post mortem vascular structure, respectively. Here, we apply both imaging modalities to a cross-sectional and longitudinal study of hippocampi vasculature in wild-type mice brains. We introduce a segmentation of CBV distribution obtained from μDoppler and show that this mice-independent and mesoscopic measurement is correlated with vessel volume fraction (VVF) distribution obtained from SLCM—e.g., high CBV relates to specific vessel locations with large VVF. Moreover, we find significant changes in CBV distribution and vasculature due to ageing (5 vs. 21 month-old mice), highlighting the sensitivity of our approach. Overall, we are able to associate CBV with vascular structure—and track its longitudinal changes—at the artery-vein, venules, arteriole, and capillary levels. We believe that this combined approach can be a powerful tool for studying other acute (e.g., brain injuries), progressive (e.g., neurodegeneration) or induced pathological changes. | es |
dc.description.sponsorship | ANII: FCE_1_2019_1_155539 | es |
dc.format.extent | 10 h. | es |
dc.format.mimetype | application/pdf | es |
dc.language.iso | en_US | es |
dc.publisher | Springer Nature | es |
dc.relation.ispartof | Scientific Reports, 2022, 12(1):6784. | es |
dc.rights | Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014) | es |
dc.subject | Ageing | es |
dc.subject | Confocal microscopy | es |
dc.subject | Imaging techniques | es |
dc.subject | Neural ageing | es |
dc.subject | Ultrasound | es |
dc.title | Intensity distribution segmentation in ultrafast Doppler combined with scanning laser confocal microscopy for assessing vascular changes associated with ageing in murine hippocampi. | es |
dc.type | Artículo | es |
dc.contributor.filiacion | Anzibar Fialho Maximiliano, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Física. | - |
dc.contributor.filiacion | Vázquez Alberdi Lucía, IIBCE | - |
dc.contributor.filiacion | Martínez Mariana, IIBCE | - |
dc.contributor.filiacion | Calero Miguel | - |
dc.contributor.filiacion | Baranger Jerome | - |
dc.contributor.filiacion | Tanter Mickael | - |
dc.contributor.filiacion | Damián Juan Pablo, Universidad de la República (Uruguay). Facultad de Veterinaria. | - |
dc.contributor.filiacion | Negreira Carlos, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Física. | - |
dc.contributor.filiacion | Rubido Nicolás, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Física. | - |
dc.contributor.filiacion | Kun González Alejandra E., Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología. | - |
dc.contributor.filiacion | Brum Javier, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Física. | - |
dc.rights.licence | Licencia Creative Commons Atribución - No Comercial - Sin Derivadas (CC - By-NC-ND 4.0) | es |
dc.identifier.doi | 10.1038/s41598-022-10457-9 | - |
Aparece en las colecciones: | Publicaciones académicas y científicas - Facultad de Ciencias |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | ||
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10.1038s4159802210579.pdf | 3,9 MB | Adobe PDF | Visualizar/Abrir |
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