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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Sarute, Nicolás | - |
dc.contributor.author | Cheng, Han | - |
dc.contributor.author | Yan, Zhonghao | - |
dc.contributor.author | Salas-Briceno, Karen | - |
dc.contributor.author | Richne, Justin | - |
dc.contributor.author | Rong, Lijun | - |
dc.contributor.author | Ross, S. R. | - |
dc.date.accessioned | 2023-07-20T15:08:04Z | - |
dc.date.available | 2023-07-20T15:08:04Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | Sarute, N, Cheng, H, Yan, Z, [y otros autores] "Signal-regulatory protein alpha is an anti-viral entry factor targeting viruses using endocytic pathways". PLoS Pathog. [en línea] 2021, 17(6): e1009662. 23 h. DOI: 10.1371/journal.ppat.1009662 | es |
dc.identifier.issn | 1553-7374 | - |
dc.identifier.uri | https://hdl.handle.net/20.500.12008/38247 | - |
dc.description.abstract | Signal-regulatory protein alpha (SIRPA) is a well-known inhibitor of phagocytosis when it complexes with CD47 expressed on target cells. Here we show that SIRPA decreased in vitro infection by a number of pathogenic viruses, including New World and Old World arena-viruses, Zika virus, vesicular stomatitis virus and pseudoviruses bearing the Machupo virus, Ebola virus and SARS-CoV-2 glycoproteins, but not HSV-1, MLV or mNoV. Moreover, mice with targeted mutation of the Sirpa gene that renders it non-functional were more suscepti ble to infection with the New World arenaviruses Junı´n virus vaccine strain Candid 1 and Tacaribe virus, but not MLV or mNoV. All SIRPA-inhibited viruses have in common the requirement for trafficking to a low pH endosomal compartment. This was clearly demonstrated with SARS-CoV-2 pseudovirus, which was only inhibited by SIRPA in cells in which it required trafficking to the endosome. Similar to its role in phagocytosis inhibition, SIRPA decreased virus internalization but not binding to cell surface receptors. We also found that increasing SIRPA levels via treatment with IL-4 led to even greater anti-viral activity. These data suggest that enhancing SIRPA’s activity could be a target for anti-viral therapies. | es |
dc.format.extent | 23 h | es |
dc.format.mimetype | application/pdf | es |
dc.language.iso | en | es |
dc.publisher | PloS ONE | es |
dc.relation.ispartof | PLoS Pathog,2021, 17(6): e1009662. | es |
dc.rights | Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014) | es |
dc.subject | Vesicular stomatitis virus | es |
dc.subject | Ebola virus | es |
dc.subject | Small interfering RNA | es |
dc.subject | Phagocytosis | es |
dc.subject | SARS CoV 2 | es |
dc.subject | 293T cells | es |
dc.subject | Transfection | es |
dc.subject | Machupo Virus | es |
dc.title | Signal-regulatory protein alpha is an anti-viral entry factor targeting viruses using endocytic pathways | es |
dc.type | Artículo | es |
dc.contributor.filiacion | Sarute Nicolás, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología. | - |
dc.contributor.filiacion | Cheng Han, University of Illinois | - |
dc.contributor.filiacion | Yan Zhonghao, University of Illinois | - |
dc.contributor.filiacion | Salas-Briceno Karen, University of Illinois | - |
dc.contributor.filiacion | Richne Justin, University of Illinois | - |
dc.contributor.filiacion | Rong Lijun, University of Illinois | - |
dc.contributor.filiacion | Ross S. R., University of Illinois | - |
dc.rights.licence | Licencia Creative Commons Atribución (CC - By 4.0) | es |
dc.identifier.doi | 10.1371/journal.ppat.1009662 | - |
Aparece en las colecciones: | Publicaciones académicas y científicas - Facultad de Ciencias |
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