Por favor, use este identificador para citar o enlazar este ítem:
https://hdl.handle.net/20.500.12008/35762
Cómo citar
Registro completo de metadatos
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Pastro, Lucía | - |
dc.contributor.author | Smircich, Pablo | - |
dc.contributor.author | Di Paolo, Andrés | - |
dc.contributor.author | Becco, Lorena | - |
dc.contributor.author | Duhagon, María Ana | - |
dc.contributor.author | Sotelo Silveira, José Roberto | - |
dc.contributor.author | Garat, Beatriz | - |
dc.date.accessioned | 2023-02-08T14:40:50Z | - |
dc.date.available | 2023-02-08T14:40:50Z | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | Pastro, L, Smircich, P, Di Paolo, A. [y otros autores]. "Nuclear compartmentalization contributes to stage-specific gene expression control in Trypanosoma cruzi". Frontiers in Cell and Developmental Biology. [en línea] 2017, 15: 517-521. 14 h. DOI: 10.3389/fcell.2017.00008 | es |
dc.identifier.issn | 2352-3409 | - |
dc.identifier.uri | https://hdl.handle.net/20.500.12008/35762 | - |
dc.description.abstract | In the protozoan parasite Trypanosoma cruzi, as in other trypanosomatids, transcription of protein coding genes occurs in a constitutive fashion, producing large polycistronic transcription units. These units are composed of non-functionally related genes which are pervasively processed to yield each mRNA. Therefore, post-transcriptional processes are crucial to regulate gene expression. Considering that nuclear ompartmentalization could contribute to gene expression regulation, we comparatively studied the nuclear, cytoplasmic and whole cell transcriptomes of the non-infective epimastigote stage of T. cruzi, using RNA-Seq. We found that the cytoplasmic transcriptome tightly correlates with the whole cell transcriptome and both equally correlate with the proteome. Nonetheless, 1,200 transcripts showed differential abundance between the nuclear and cytoplasmic fractions. For the genes with transcript content augmented in the nucleus, significant structural and ompositional differences were found. The analysis of the reported epimastigote translatome and proteome, revealed scarce ribosome footprints and encoded proteins for them. Ontology analyses unveiled that many of these genes are distinctive of other parasite life-cycle stages. Finally, the relocalization of transcript abundance in the metacyclic trypomastigote infective stage was confirmed for specific genes. While gene expression is strongly dependent on transcript steady-state level, we here highlight the importance of the distribution of ranscripts abundance between compartments in T. cruzi. Particularly, we show that nuclear compartmentation is playing an active role in the developmental stage determination preventing off-stage expression. | es |
dc.format.extent | 14 h. | es |
dc.format.mimetype | application/pdf | es |
dc.language.iso | en_US | es |
dc.publisher | Frontiers Media | es |
dc.relation.ispartof | Frontiers in Cell and Developmental Biology, 2017, 15: 517-521. | es |
dc.rights | Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014) | es |
dc.subject | Gene expression regulation | es |
dc.subject | RNA-Seq | es |
dc.subject | Subcellular fractionation | es |
dc.subject | Trypanosomes | es |
dc.subject | Differentiation | es |
dc.subject | Life cycle | es |
dc.title | Nuclear compartmentalization contributes to stage-specific gene expression control in Trypanosoma cruzi | es |
dc.type | Artículo | es |
dc.contributor.filiacion | Pastro Lucía, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología. | - |
dc.contributor.filiacion | Smircich Pablo, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología. | - |
dc.contributor.filiacion | Di Paolo Andrés, Universidad de la República (Uruguay). Facultad de Medicina. | - |
dc.contributor.filiacion | Becco Lorena, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología. | - |
dc.contributor.filiacion | Duhagon María Ana, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología. | - |
dc.contributor.filiacion | Sotelo Silveira José Roberto, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología. | - |
dc.contributor.filiacion | Garat Beatriz, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología. | - |
dc.rights.licence | Licencia Creative Commons Atribución - No Comercial - Sin Derivadas (CC - By-NC-ND 4.0) | es |
dc.identifier.doi | 10.3389/fcell.2017.00008 | - |
Aparece en las colecciones: | Publicaciones académicas y científicas - Facultad de Ciencias |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | ||
---|---|---|---|---|---|
10.3389fcell.2017.00008.pdf | 2,42 MB | Adobe PDF | Visualizar/Abrir |
Este ítem está sujeto a una licencia Creative Commons Licencia Creative Commons