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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Bologna-Molina, Ronell | - |
dc.contributor.author | Mosqueda Taylor, Adalberto | - |
dc.contributor.author | Molina Frechero, Nelly | - |
dc.contributor.author | Mori Estevez, Ana Dolores | - |
dc.contributor.author | Sánchez Acuña, Guillermo | - |
dc.date.accessioned | 2022-05-06T15:31:43Z | - |
dc.date.available | 2022-05-06T15:31:43Z | - |
dc.date.issued | 2013 | - |
dc.identifier.citation | Bologna-Molina, R, Mosqueda Taylor, A, Molina Frechero, N.y otros. "Comparison of the value of PCNA and Ki-67 as markers of cell proliferation in ameloblastic tumors"Med Oral Patol Oral Cir Bucal. 2013 Mar 1;18 (2):e174-9. [en línea] 2013. doi:10.4317/medoral.18573 | es |
dc.identifier.uri | https://hdl.handle.net/20.500.12008/31502 | - |
dc.description.abstract | The aim of this study was to compare among PCNAand Ki-67 as the most reliable immunohistochemical marker for evaluating cell proliferation in ameloblastic tumors. Study design: Observational, retrospective, and descriptive study of a large series of ameloblastic tumors, composed of 161 ameloblastomas and four ameloblastic carcinomas, to determine and compare PCNA and Ki-67 expression using immunohistochemistry techniques. Results: When analyzing Ki-67 positivity, the desmoplastic ameloblastoma demonstrated a significantly lower proliferation rate (1.9%) compared with the solid/multicystic and unicystic ameloblastomas and ameloblastic carcinomas (p<0.05), whereas the ameloblastic carcinomas displayed a significantly higher rate compared with all of the other ameloblastomas (48.7%) (p<0.05). When analyzing cell proliferation with PCNA, we found significant differences only between the ameloblastic carcinomas (93.3%) and the desmoplastic ameloblastomas (p<0.05). When differences between the immunopositivity for PCNA and Ki-67 were compared, the percentages were higher for PCNA in all types of ameloblastomas and ameloblastic carcinomas. In all cases, the percentages were greater than 80%, whereas the immunopositivity for Ki-67 was significantly lower; for example, the ameloblastic carcinoma expressed the highest positivity and only reached 48.7%, compared to 93.3% when we used PCNA. Conclusions: In the present study, when we used the proliferation cell marker Ki-67, the percentages of positivity were more specific and varied among the different types of ameloblastomas, suggesting that Ki-67 is a more specific marker for the proliferation of ameloblastic tumor cells. | es |
dc.format.mimetype | application/pdf | es |
dc.language.iso | en | es |
dc.relation.ispartof | Med Oral Patol Oral Cir Bucal. 2013 Mar 1;18 (2):e174-9. | es |
dc.rights | Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014) | es |
dc.subject | Ameloblastomas | es |
dc.subject | Ameloblastic carcinoma | es |
dc.subject | PCNA | es |
dc.subject | Ki-67 | es |
dc.subject | Cell proliferation markers | es |
dc.subject.other | ANTIGENO Ki-67 | es |
dc.subject.other | ANTIGENO NUCLEAR DE CELULA EN PROLIFERACION | es |
dc.subject.other | CARCINOMA | es |
dc.subject.other | AMELOBLASTOMA | es |
dc.title | Comparison of the value of PCNA and Ki-67 as markers of cell proliferation in ameloblastic tumors | es |
dc.type | Artículo | es |
dc.contributor.filiacion | Bologna-Molina Ronell, Research Department, School of Dentistry, Universidad Juárez del Estado de Durango (UJED), Durango, México .School of Dentistry, Universidad de la República (UDELAR). Montevideo, Uruguay | - |
dc.contributor.filiacion | Mosqueda Taylor Adalberto, Health Care Department, Universidad Autónoma Metropolitana, Xochimilco. Mexico | - |
dc.contributor.filiacion | Molina Frechero Nelly, Health Care Department, Universidad Autónoma Metropolitana, Xochimilco. Mexico | - |
dc.contributor.filiacion | Mori Estevez Ana Dolores, Pathology Department , Hospital Universitario “Gral. Calixto García” La Havana, Cuba | - |
dc.contributor.filiacion | Sánchez Acuña Guillermo, Maxillofacial Department, Hospital Universitario “Gral. Calixto García” La Havana, Cuba | - |
dc.rights.licence | Licencia Creative Commons Atribución - No Comercial (CC - By-NC 4.0) | es |
dc.identifier.doi | doi:10.4317/medoral.18573 | - |
Aparece en las colecciones: | Publicaciones Académicas y científicas hasta 2019 - Facultad de Odontología |
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Comparison of the value of PCNA and Ki-67 as markers of cell proliferation in ameloblastic tumors.pdf | 715,58 kB | Adobe PDF | Visualizar/Abrir |
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