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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | López Verdín, Sandra | - |
dc.contributor.author | Lavalle Carrasco, Jesus | - |
dc.contributor.author | Carreón Burciaga, Ramón Gil | - |
dc.contributor.author | Serafín Higuera, Nicolás | - |
dc.contributor.author | Molina Frechero, Nelly | - |
dc.contributor.author | González González, Rogelio | - |
dc.contributor.author | Bologna-Molina, Ronell | - |
dc.date.accessioned | 2022-05-05T13:46:55Z | - |
dc.date.available | 2022-05-05T13:46:55Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | López Verdín, S, Lavalle Carrasco, J, Carreón Burciaga, R. "Molecular Markers of Anticancer Drug Resistance in Head and Neck Squamous Cell Carcinoma: A Literature Review". Cancers 2018. [en línea] 2018 Vol. 10, 376 doi:10.3390/cancers10100376. | es |
dc.identifier.uri | https://hdl.handle.net/20.500.12008/31436 | - |
dc.description.abstract | This manuscript provides an update to the literature on molecules with roles in tumor resistance therapy in head and neck squamous cell carcinoma (HNSCC). Although significant improvements have been made in the treatment for head and neck squamous cell carcinoma, physicians face yet another challenge—that of preserving oral functions, which involves the use of multidisciplinary therapies, such as multiple chemotherapies (CT) and radiotherapy (RT). Designing personalized therapeutic options requires the study of genes involved in drug resistance. This review provides an overview of the molecules that have been linked to resistance to chemotherapy in HNSCC, including the family of ATP-binding cassette transporters (ABCs), nucleotide excision repair/base excision repair (NER/BER) enzymatic complexes (which act on nonspecific DNA lesions generated by gamma and ultraviolet radiation by cross-linking and forming intra/interchain chemical adducts), cisplatin (a chemotherapeutic agent that causes DNA damage and induces apoptosis, which is a paradox because its effectiveness is based on the integrity of the genes involved in apoptotic signaling pathways), and cetuximab, including a discussion of the genes involved in the cell cycle and the proliferation of possible markers that confer resistance to cetuximab. | en |
dc.format.mimetype | application/pdf | es |
dc.language.iso | en | es |
dc.relation.ispartof | Cancers 2018, Vol.10, 376 | es |
dc.rights | Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014) | es |
dc.subject | Oral squamous cell carcinom | en |
dc.subject | Drug resistance | en |
dc.subject | Epigenetics | en |
dc.subject.other | CARCINOMA DE CELULAS ESCAMOSAS | es |
dc.subject.other | NEOPLASIAS DE CABEZA Y CUELLO | es |
dc.subject.other | RESISTENCIA A ANTINEOPLASICOS | es |
dc.title | Molecular Markers of Anticancer Drug Resistance in Head and Neck Squamous Cell Carcinoma: A Literature Review | en |
dc.type | Artículo | es |
dc.contributor.filiacion | López Verdín Sandra, Research Institute of Dentistry, Health Science Center, Universidad de Guadalajara, | - |
dc.contributor.filiacion | Lavalle Carrasco Jesus, Department of Research, School of Dentistry, Universidad Juárez del Estado de Durango | - |
dc.contributor.filiacion | Carreón Burciaga Ramón Gil., Department of Research, School of Dentistry, Universidad Juárez del Estado de Durango | - |
dc.contributor.filiacion | Serafín Higuera Nicolás, Molecular Biology Department, School of Dentistry, Universidad Autónoma de Baja California, | - |
dc.contributor.filiacion | Molina Frechero Nelly, Department of Health Care, Xochimilco Unit, Universidad Autónoma Metropolitana (UAM) Xochimilco | - |
dc.contributor.filiacion | González González Rogelio, Department of Research, School of Dentistry, Universidad Juárez del Estado de Durango | - |
dc.contributor.filiacion | Bologna Molina Ronell, Department of Research, School of Dentistry, Universidad Juárez del Estado de Durango. Molecular Pathology Area, School of Dentistry, Universidad de la República, Montevideo 11600, Uruguay | - |
dc.rights.licence | Licencia Creative Commons Atribución - No Comercial (CC - By-NC 4.0) | es |
dc.identifier.doi | doi:10.3390/cancers10100376 | - |
Aparece en las colecciones: | Publicaciones Académicas y científicas hasta 2019 - Facultad de Odontología |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | ||
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Molecular markers of anticancer drug resistance in head and neck squamous cell carcinoma.pdf | 666,43 kB | Adobe PDF | Visualizar/Abrir |
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