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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Lamas Bervejillo, María | - |
dc.contributor.author | Bonanata, Jenner | - |
dc.contributor.author | Franchini, G. R. | - |
dc.contributor.author | Richeri Corral, Analía | - |
dc.contributor.author | Marqués, Juan Martín | - |
dc.contributor.author | Freeman, B.A. | - |
dc.contributor.author | Schopfer, F.J. | - |
dc.contributor.author | Coitiño, Laura E. | - |
dc.contributor.author | Córsico, B. | - |
dc.contributor.author | Rubbo, Homero | - |
dc.contributor.author | Ferreira, Ana María | - |
dc.date.accessioned | 2022-02-17T14:21:24Z | - |
dc.date.available | 2022-02-17T14:21:24Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Lamas Bervejillo, M, Bonanata, J, Franchini, G, [y otros] "A FABP4-PPARγ signaling axis regulates human monocyte responses to electrophilic fatty acid nitroalkenes". Redox Biology. [en línea] 2020, 29: 101376. 15 h. DOI: 10.1016/j.redox.2019.101376 | es |
dc.identifier.issn | 2213-2317 | - |
dc.identifier.uri | https://hdl.handle.net/20.500.12008/30855 | - |
dc.description.abstract | Nitro-fatty acids (NO2-FA) are electrophilic lipid mediators derived from unsaturated fatty acid nitration. These species are produced endogenously by metabolic and inflammatory reactions and mediate anti-oxidative and anti-inflammatory responses. NO2-FA have been postulated as partial agonists of the Peroxisome Proliferator- Activated Receptor gamma (PPARγ), which is predominantly expressed in adipocytes and myeloid cells. Herein, we explored molecular and cellular events associated with PPARγ activation by NO2-FA in monocytes and macrophages. NO2-FA induced the expression of two PPARγ reporter genes, Fatty Acid Binding Protein 4 (FABP4) and the scavenger receptor CD36, at early stages of monocyte differentiation into macrophages. These responses were inhibited by the specific PPARγ inhibitor GW9662. Attenuated NO2-FA effects on PPARγ sig- naling were observed once cells were differentiated into macrophages, with a significant but lower FABP4 up- regulation, and no induction of CD36. Using in vitro and in silico approaches, we demonstrated that NO2-FA bind to FABP4. Furthermore, the inhibition of monocyte FA binding by FABP4 diminished NO2-FA-induced upre- gulation of reporter genes that are transcriptionally regulated by PPARγ, Keap1/Nrf2 and HSF1, indicating that FABP4 inhibition mitigates NO2-FA signaling actions. Overall, our results affirm that NO2-FA activate PPARγ in monocytes and upregulate FABP4 expression, thus promoting a positive amplification loop for the downstream signaling actions of this mediator. | en |
dc.format.extent | 15 h. | es |
dc.format.mimetype | application/pdf | es |
dc.language.iso | en | es |
dc.publisher | Elsevier | es |
dc.relation.ispartof | Redox Biology, 2020, 29: 101376 | es |
dc.rights | Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014) | es |
dc.subject | Nitro-fatty acids | es |
dc.subject | Peroxisome proliferator-activated receptor gamma | en |
dc.subject | Fatty acid binding protein 4 | en |
dc.subject | Monocytes | en |
dc.subject | Macrophages | en |
dc.subject | Lipid signaling | en |
dc.title | A FABP4-PPARγ signaling axis regulates human monocyte responses to electrophilic fatty acid nitroalkenes | en |
dc.type | Artículo | es |
dc.contributor.filiacion | Lamas Bervejillo María, Universidad de la República (Uruguay). Facultad de Ciencias. | - |
dc.contributor.filiacion | Bonanata Jenner, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Química Biológica. | - |
dc.contributor.filiacion | Franchini G. R. | - |
dc.contributor.filiacion | Richeri A., IIBCE | - |
dc.contributor.filiacion | Marqués Juan Martín, Universidad de la República (Uruguay). Facultad de Medicina. | - |
dc.contributor.filiacion | Freeman B. A. | - |
dc.contributor.filiacion | Schopfer F. J. | - |
dc.contributor.filiacion | Coitiño Laura E., Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Química Biológica. | - |
dc.contributor.filiacion | Córsico B. | - |
dc.contributor.filiacion | Rubbo Homero, Universidad de la República (Uruguay). Facultad de Medicina. | - |
dc.contributor.filiacion | Ferreira Ana María, Universidad de la República (Uruguay). Facultad de Ciencias. | - |
dc.rights.licence | Licencia Creative Commons Atribución (CC - By 4.0) | es |
dc.identifier.doi | 10.1016/j.redox.2019.101376 | - |
Aparece en las colecciones: | Publicaciones académicas y científicas - Facultad de Ciencias |
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10.1016j.redox.2019.101376.pdf | 2,74 MB | Adobe PDF | Visualizar/Abrir |
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