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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Fresia, Pablo | - |
dc.contributor.author | Antelo Gutiérrez, Verónica Beatriz | - |
dc.contributor.author | Salazar González, María Cecilia | - |
dc.contributor.author | Giménez Martínez, Matías | - |
dc.contributor.author | D’Alessandro, Bruno | - |
dc.contributor.author | Afshinnekoo, E. | - |
dc.contributor.author | Mason, C. | - |
dc.contributor.author | Gonnet, Gastón H. | - |
dc.contributor.author | Iraola, Gregorio | - |
dc.date.accessioned | 2021-05-26T12:11:08Z | - |
dc.date.available | 2021-05-26T12:11:08Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Fresia, P, Antelo, V, Salazar González, M, y otros "Urban metagenomics uncover antibiotic resistance reservoirs in coastal beach and sewage waters". Microbiome. [en línea] 2019, 7: 35. 9 h. DOI: 10.1186/s40168-019-0648-z | es |
dc.identifier.issn | 2049-2618 | - |
dc.identifier.uri | https://hdl.handle.net/20.500.12008/27874 | - |
dc.description.abstract | Background: Microbial communities present in environmental waters constitute a reservoir for antibiotic-resistant pathogens that impact human health. For this reason, a diverse variety of water environments are being analyzed using metagenomics to uncover public health threats. However, the composition of these communities along the coastal environment of a whole city, where sewage and beach waters are mixed, is poorly understood. Results: We shotgun-sequenced 20 coastal areas from the city of Montevideo (capital of Uruguay) including beach and sewage water samples to characterize bacterial communities and their virulence and antibiotic resistance repertories. As expected, we found that sewage and beach environments present significantly different bacterial communities. This baseline allowed us to detect a higher prevalence and a more diverse repertory of virulence and antibiotic-resistant genes in sewage samples. Many of these genes come from well-known enterobacteria and represent carbapenemases and extended-spectrum betalactamases reported in hospital infections in Montevideo. Additionally, we were able to genotype the presence of both globally disseminated pathogenic clones and emerging antibiotic-resistant bacteria in sewage waters. Conclusions: Our study represents the first in using metagenomics to jointly analyze beaches and the sewage system from an entire city, allowing us to characterize antibiotic-resistant pathogens circulating in urban waters. The data generated in this initial study represent a baseline metagenomic exploration to guide future longitudinal (time-wise) studies, whose systematic implementation will provide useful epidemiological information to improve public health surveillance. | es |
dc.format.extent | 9 h. | es |
dc.format.mimetype | application/pdf | es |
dc.language.iso | en | es |
dc.publisher | BMC | es |
dc.relation.ispartof | Microbiome, 2019, 7: 35 | es |
dc.rights | Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014) | es |
dc.subject | Sewage | es |
dc.subject | Beach | es |
dc.subject | Metagenomics | es |
dc.subject | Taxonomy | es |
dc.subject | Antimicrobial resistance | es |
dc.subject | Bacterial pathogens | es |
dc.title | Urban metagenomics uncover antibiotic resistance reservoirs in coastal beach and sewage waters | es |
dc.type | Artículo | es |
dc.contributor.filiacion | Fresia Pablo, Instituto Pasteur (Montevideo). | - |
dc.contributor.filiacion | Antelo Gutiérrez Verónica Beatriz, Instituto Pasteur (Montevideo). | - |
dc.contributor.filiacion | Salazar González María Cecilia, Instituto Pasteur (Montevideo). | - |
dc.contributor.filiacion | Giménez Martínez Matías, Instituto Pasteur (Montevideo). | - |
dc.contributor.filiacion | D’Alessandro Bruno, Intendencia (Montevideo). | - |
dc.contributor.filiacion | Afshinnekoo E. | - |
dc.contributor.filiacion | Mason C. | - |
dc.contributor.filiacion | Gonnet Gastón H., Instituto Pasteur (Montevideo). | - |
dc.contributor.filiacion | Iraola Gregorio, Instituto Pasteur (Montevideo). | - |
dc.rights.licence | Licencia Creative Commons Atribución (CC - By 4.0) | es |
dc.identifier.doi | 10.1186/s40168-019-0648-z | - |
Aparece en las colecciones: | Publicaciones académicas y científicas - Facultad de Ciencias |
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Fichero | Descripción | Tamaño | Formato | ||
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10.1186s40168-019-0648-z.pdf | 1,97 MB | Adobe PDF | Visualizar/Abrir |
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