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| Título: | Microwave-assisted solid-phase synthesis of nicotinyl hydrazones for use in radiochemistry of technetium-99m |
| Autor: | Teixeira, Vania Cabral González, Pablo Porcal, Williams |
| Tipo: | Artículo |
| Palabras clave: | Chelation, Hydrazone, HYNIC, Microwave, Solid-phase, Technetium-99m |
| Fecha de publicación: | 2018 |
| Resumen: | We report a new method for efficient and rapid synthesis of HYNIC-hydrazone derivatives using microwaveassisted solid-phase. In comparison to the conventional heating procedure, microwave irradiation considerably accelerated the formation of HYNIC analogues. The synthesis time and efforts are significantly reduced in the present method, without side product formation. We proved that the HYNIC-hydrazone clustering can be directly labeled with technetium without exposing the free hydrazine group. Therefore, this is a useful tool to obtain HYNIC-bioconjugates for use in 99mTc radiochemistry. |
| Editorial: | Arkat |
| EN: | Arkivoc, 2018, (5), pp. 29-38. |
| Citación: | Teixeira, V, Cabral González, P y Porcal, W. "Microwave-assisted solid-phase synthesis of nicotinyl hydrazones for use in radiochemistry of technetium-99m". Arkivoc. [en línea] 2018, (5), pp. 29-38. 10 h. doi: 10.24820/ark.5550190.p010.065 |
| ISSN: | 1551-7004 |
| Aparece en las colecciones: | Publicaciones académicas y científicas - Facultad de Ciencias |
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| Fichero | Descripción | Tamaño | Formato | ||
|---|---|---|---|---|---|
| 1024820ark5550190p010065.pdf | 1,32 MB | Adobe PDF | Visualizar/Abrir |
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