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Título: The epithelial sodium channel and the processes of wound healing
Autor: Chifflet, Silvia
Hernández, Julio
Tipo: Artículo
Palabras clave: Epithelial sodium channel, Cell communication
Fecha de publicación: 2016
Resumen: The epithelial sodium channel (ENaC) mediates passive sodium transport across the apical membranes of sodium absorbing epithelia, like the distal nephron, the intestine, and the lung airways. Additionally, the channel has been involved in the transduction of mechanical stimuli, such as hydrostatic pressure, membrane stretch, and shear stress from fluid flow. Thus, in vascular endothelium, it participates in the control of the vascular tone via its activity both as a sodium channel and as a shear stress transducer. Rather recently, ENaC has been shown to participate in the processes of wound healing, a role that may also involve its activities as sodium transporter and as mechanotransducer. Its presence as the sole channel mediating sodium transport in many tissues and the diversity of its functions probably underlie the complexity of its regulation. This brief review describes some aspects of ENaC regulation, comments on evidence about ENaC participation in wound healing, and suggests possible regulatory mechanisms involved in this participation.
Editorial: Hindawi Publishing Corporation
EN: BioMed Research International, 2016, art. no. 5675047
DOI: 10.1155/2016/5675047
ISSN: 2314-6133
Citación: Chifflet, S., Hernandez, J.The epithelial sodium channel and the processes of wound healing. BioMed Research International, 2016, art. no. 5675047. doi: 10.1155/2016/5675047
Licencia: Licencia Creative Commons Atribución (CC –BY 4.0)
Aparece en las colecciones: Publicaciones académicas y científicas - Facultad de Ciencias

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