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Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Vierci, Gabriela | es |
dc.contributor.author | Pannunzio, Bruno | es |
dc.contributor.author | Bornia De León, Natalia | es |
dc.contributor.author | Rossi, Francesco Mattia | es |
dc.date.accessioned | 2019-10-02T22:12:09Z | - |
dc.date.available | 2019-10-02T22:12:09Z | - |
dc.date.issued | 2016 | es |
dc.date.submitted | 20190930 | es |
dc.identifier.citation | Vierci, G., et al. H3 and H4 Lysine acetylation correlates with developmental and experimentally induced adult experience-dependent plasticity in the mouse visual cortex. Journal of Experimental Neuroscience, 2016, 10 (s1): 49-64.doi: 10.4137/JEN.S39888 | es |
dc.identifier.issn | 1179-0695 | es |
dc.identifier.uri | https://hdl.handle.net/20.500.12008/22065 | - |
dc.description.abstract | Histone posttranslational modifications play a fundamental role in orchestrating gene expression. In this work, we analyzed the acetylation of H3 and H4 histones (AcH3-AcH4) and its modulation by visual experience in the mouse visual cortex (VC) during normal development and in two experimental conditions that restore juvenile-like plasticity levels in adults (fluoxetine treatment and enriched environment). We found that AcH3-AcH4 declines with age and is upregulated by treatments restoring plasticity in the adult. We also found that visual experience modulates AcH3-AcH4 in young and adult plasticity-restored mice but not in untreated ones. Finally, we showed that the transporter vGAT is downregulated in adult plasticity-restored models. In summary, we identified a dynamic regulation of AcH3-AcH4, which is associated with high plasticity levels and enhanced by visual experience. These data, along with recent ones, indicate H3-H4 acetylation as a central hub in the control of experience-dependent plasticity in the VC | es |
dc.format.mimetype | application/pdf | es |
dc.language.iso | en | es |
dc.publisher | Libertas Academica | es |
dc.relation.ispartof | Journal of Experimental Neuroscience, 2016, 10 (s1): 49-64 | es |
dc.rights | Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad De La República. (Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014) | es |
dc.subject | Visual cortex plasticity | es |
dc.subject | Histone acetylation | es |
dc.subject | Vesicular transporters | es |
dc.subject | Development | es |
dc.subject | Fluoxetine | es |
dc.subject | Enriched environment | es |
dc.title | H3 and H4 Lysine acetylation correlates with developmental and experimentally induced adult experience-dependent plasticity in the mouse visual cortex | es |
dc.type | Artículo | es |
dc.contributor.filiacion | Vierci, Gabriela. Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología | es |
dc.contributor.filiacion | Pannunzio, Bruno. Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología | es |
dc.contributor.filiacion | Bornia De León, Natalia. Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología | es |
dc.contributor.filiacion | Rossi, Francesco M. Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología. | es |
dc.rights.licence | Licencia Creative Commons Atribución – No Comercial (CC -BY-NC 4.0) | es |
dc.identifier.doi | 10.4137/JEN.S39888 | es |
Aparece en las colecciones: | Publicaciones académicas y científicas - Facultad de Ciencias |
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104137JENS39888.pdf | 2,85 MB | Adobe PDF | Visualizar/Abrir |
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