Por favor, use este identificador para citar o enlazar este ítem:
https://hdl.handle.net/20.500.12008/22050
Cómo citar
Registro completo de metadatos
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Valansi, C. | es |
dc.contributor.author | Moi, D. | es |
dc.contributor.author | Leikina, E. | es |
dc.contributor.author | Matveev, E. | es |
dc.contributor.author | Graña Alfonso, Martín | es |
dc.contributor.author | Chernomordik, L. | es |
dc.contributor.author | Romero Brunetto, Héctor Gabriel | es |
dc.contributor.author | Aguilar, Pablo S. | es |
dc.contributor.author | Podbilewicz, B. | es |
dc.date.accessioned | 2019-10-02T22:12:04Z | - |
dc.date.available | 2019-10-02T22:12:04Z | - |
dc.date.issued | 2017 | es |
dc.date.submitted | 20190930 | es |
dc.identifier.citation | Valansi, C., et al.Arabidopsis HAP2/GCS1 is a gamete fusion protein homologous to somatic and viral fusogens. Journal of Cell Biology, 2017, 216 (3): 571–581. doi: 10.1083/jcb.201610093 | es |
dc.identifier.issn | 1540-8140 | es |
dc.identifier.uri | https://hdl.handle.net/20.500.12008/22050 | - |
dc.description.abstract | Cell–cell fusion is inherent to sexual reproduction. Loss of HAPLESS 2/GENERATIVE CELL SPECIFIC 1 (HAP2/GCS1) proteins results in gamete fusion failure in diverse organisms, but their exact role is unclear. In this study, we show that Arabidopsis thaliana HAP2/GCS1 is sufficient to promote mammalian cell–cell fusion. Hemifusion and complete fusion depend on HAP2/GCS1 presence in both fusing cells. Furthermore, expression of HAP2 on the surface of pseudotyped vesicular stomatitis virus results in homotypic virus–cell fusion. We demonstrate that the Caenorhabditis elegans Epithelial Fusion Failure 1 (EFF-1) somatic cell fusogen can replace HAP2/GCS1 in one of the fusing membranes, indicating that HAP2/GCS1 and EFF-1 share a similar fusion mechanism. Structural modeling of the HAP2/GCS1 protein family predicts that they are homologous to EFF-1 and viral class II fusion proteins (e.g., Zika virus). We name this superfamily Fusexins: fusion proteins essential for sexual reproduction and exoplasmic merger of plasma membranes. We suggest a common origin and evolution of sexual reproduction, enveloped virus entry into cells, and somatic cell fusion. | es |
dc.format.mimetype | application/pdf | es |
dc.language.iso | en | es |
dc.publisher | Rockefeller University Press | es |
dc.relation.ispartof | Journal of Cell Biology, 2017, 216 (3): 571–581 | es |
dc.rights | Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad De La República. (Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014) | es |
dc.subject | Sexual reproduction | es |
dc.subject | Gametes | es |
dc.subject | Cell fusion | es |
dc.title | Arabidopsis HAP2/GCS1 is a gamete fusion protein homologous to somatic and viral fusogens | es |
dc.type | Artículo | es |
dc.contributor.filiacion | Romero Brunetto, Héctor Gabriel. Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología | es |
dc.contributor.filiacion | Graña Alfonso, Martín. Instituto Pasteur (Montevideo) | es |
dc.rights.licence | Licencia Creative Commons Atribución – No Comercial -- Compartir igual (CC -BY-NC-SA 4.0) | es |
dc.identifier.doi | 10.1083/jcb.201610093 | es |
Aparece en las colecciones: | Publicaciones académicas y científicas - Facultad de Ciencias |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | ||
---|---|---|---|---|---|
101083jcb201610093.pdf | 2,02 MB | Adobe PDF | Visualizar/Abrir |
Este ítem está sujeto a una licencia Creative Commons Licencia Creative Commons