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Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Noya, Verónica | es |
dc.contributor.author | Brossard Barbosa, Natalie | es |
dc.contributor.author | Rodríguez, Ernesto | es |
dc.contributor.author | Dergan-Dylon, L. S. | es |
dc.contributor.author | Carmona García, Carlos | es |
dc.contributor.author | Rabinovich, G. A. | es |
dc.contributor.author | Freire, Teresa | es |
dc.date.accessioned | 2019-10-02T22:08:26Z | - |
dc.date.available | 2019-10-02T22:08:26Z | - |
dc.date.issued | 2017 | es |
dc.date.submitted | 20190930 | es |
dc.identifier.citation | Noya, V.,et al. "A mucin-like peptide from Fasciola hepatica instructs dendritic cells with parasite specific Th1-polarizing activity". Scientific Reports, 2017, 7, art. nro. 40615.doi: 10.1038/srep40615 | es |
dc.identifier.issn | 2045-2322 | es |
dc.identifier.uri | https://hdl.handle.net/20.500.12008/22012 | - |
dc.description.abstract | Fasciolosis is a trematode zoonosis of interest in public health and cattle production. We report here the immunostimulatory effect of a 66 mer mucin-like peptide from Fasciola hepatica (Fhmuc), which synergizes with lipopolysaccharide (LPS) to promote dendritic cell (DC) maturation, endowing these cells with Th1-polarizing capacity. Exposure of DCs to Fhmuc in presence of LPS induced enhanced secretion of pro-inflammatory cytokines and expression of co-stimulatory molecules by DCs, promoting their T cell stimulatory capacity and selectively augmenting IFN-3 secretion by allogeneic T cells. Furthermore, exposure of DCs to Fhmuc augmented LPS-induced Toll-like receptor (TLR) 4 expression on the cell surface. Finally, Fhmuc-conditioned DCs induced parasite specific-adaptive immunity with increased levels of IFN-3 secreted by splenocytes from vaccinated animals, and higher parasite-specific IgG antibodies. However, Fhmuc-treated DC conferred modest protection against F. hepatica infection highlighting the potent immuno-regulatory capacity of the parasite. In summary, this work highlights the capacity of a mucin-derived peptide from F. hepatica to enhance LPS-maturation of DCs and induce parasite-specific immune responses with potential implications in vaccination and therapeutic strategies. | es |
dc.format.mimetype | application/pdf | es |
dc.language.iso | en | es |
dc.publisher | Nature Publishing Group | es |
dc.relation.ispartof | Scientific Reports, 2017, 7, art. no. 40615 | es |
dc.rights | Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad De La República. (Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014) | es |
dc.subject | Fasciola hepatica | es |
dc.subject | Parasites | es |
dc.subject | Helminth antibody | es |
dc.title | A mucin-like peptide from Fasciola hepatica instructs dendritic cells with parasite specific Th1-polarizing activity | es |
dc.type | Artículo | es |
dc.contributor.filiacion | Noya, Verónica. Universidad de la República (Uruguay). Facultad de Medicina | es |
dc.contributor.filiacion | Brossard, Natalia. Universidad de la República (Uruguay). Facultad de Medicina | es |
dc.contributor.filiacion | Rodríguez, Ernesto. Universidad de la República (Uruguay). Facultad de Medicina | es |
dc.contributor.filiacion | Carmona, Carlos. Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología | es |
dc.contributor.filiacion | Freire, Teresa. Universidad de la República (Uruguay). Facultad de Medicina. | es |
dc.rights.licence | Licencia Creative Commons Atribución (CC –BY 4.0) | es |
dc.identifier.doi | 10.1038/srep40615 | es |
Aparece en las colecciones: | Publicaciones académicas y científicas - Facultad de Ciencias |
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101038srep40615.pdf | 1,55 MB | Adobe PDF | Visualizar/Abrir |
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