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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Gómez, Maria. A | - |
dc.contributor.author | Migues, Ignacio | - |
dc.contributor.author | Caggiani, Maria | - |
dc.contributor.author | Arias, Ximena | - |
dc.contributor.author | Laprovitera, Mariajose | - |
dc.contributor.author | Blanco, Fabiana | - |
dc.contributor.author | Cesio, Maria Veronica | - |
dc.contributor.author | Migliaro, Eduardo R. | - |
dc.contributor.author | Heinzen, Horacio | - |
dc.date.accessioned | 2019-09-26T15:49:53Z | - |
dc.date.available | 2019-09-26T15:49:53Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | Gómez, M, Migues, I, Caggiani, M, y otros. "Vasorelaxant Effect of a Baccharis trimera Infusion on Precontracted Rat Aortic Rings". Natural Product Communications Vol. 11 (0) 2016 [en línea] | es |
dc.identifier.issn | 1934-578X | - |
dc.identifier.uri | https://hdl.handle.net/20.500.12008/21974 | - |
dc.description.abstract | Baccharis trimera (Less.) DC is a South American plant that in folk medicine is considered to produce reduction in blood pressure. One aspect of this putative effect is the vasorelaxation. The aim of this work was to evaluate the ability of a B. trimera extract to relax rat aortic rings precontracted with noradrenaline. As the infusion is the usual way of intake of this plant, an infusion of B. trimera was prepared using 100g of the plant (leaves) boiled in water, frozen and lyophilized. Working solutions were prepared using different concentrations of the dried extract diluted in Krebs Henseleit solution. It was proved that the infusion relaxed the aortic rings in a dose dependent manner 100 minutes after adding the extract to the bath. Considering as 100% the maximum contraction achieved with noradrenaline, a relaxation of 101.1±2.3% was observed with the highest dose of the infusion used in these experiments (0.32mg/mL). While in control rings relaxation was 12.9±2.4%. In aortic rings denuded from endothelium the percentage of vasoralaxation did not show statistically significant differences when compared to intact rings. These data support the hypothesis of a vasorelaxant effect of this plant and constitutes the first approach to the scientific basis of a potential antihypertensive effect. | es |
dc.format.mimetype | application/pdf | - |
dc.language.iso | en | es |
dc.publisher | SAGE Publishing | es |
dc.relation.ispartof | Natural Product Communications Vol. 11 (0) 2016 | es |
dc.rights | Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014) | es |
dc.subject | Hypertension | es |
dc.subject | Cardiovascular | es |
dc.subject | Traditional medicine | es |
dc.subject | Meso-and Southtern American | es |
dc.subject | Baccharis trimera | es |
dc.subject | Vasorelaxation | es |
dc.subject | Aortic rings | es |
dc.title | Vasorelaxant Effect of a Baccharis trimera Infusion on Precontracted Rat Aortic Rings | es |
dc.type | Artículo | es |
dc.contributor.filiacion | Gómez Maria. A | - |
dc.contributor.filiacion | Migues Ignacio | - |
dc.contributor.filiacion | Caggiani Maria | - |
dc.contributor.filiacion | Arias Ximena | - |
dc.contributor.filiacion | Laprovitera Mariajose | - |
dc.contributor.filiacion | Blanco Fabiana | - |
dc.contributor.filiacion | Cesio Maria Veronica | - |
dc.contributor.filiacion | Migliaro Eduardo R. | - |
dc.contributor.filiacion | Heinzen Horacio | - |
dc.rights.licence | Licencia Creative Commons Atribución – No Comercial – Sin Derivadas (CC BY-NC-ND 4.0) | - |
dc.identifier.doi | https://doi.org/10.1177/1934578X1601100304 | - |
Aparece en las colecciones: | Publicaciones Académicas y Científicas - Facultad de Medicina |
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