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Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12008/18482 How cite
Title: Evaluation of the osteoclastogenic process associated with RANK / RANK-L / OPG in odontogenic myxomas
Authors: González Galván, María del Carmen
Mosqueda Taylor, Adalberto
Bologna Molina, Ronell
Setien Olarra, A.
Marichalar Mendia, Xabier
Aguirre Urizar, José Manuel
Type: Artículo científico
Keywords: Odontogenic myxoma, Dental follicle, RANK, RANK-L, OPG, Osteoclastogenesis.
Issue Date: 2018
Abstract: Background: Odontogenic myxoma (OM) is a benign intraosseous neoplasm that exhibits local aggressiveness and high recurrence rates. Osteoclastogenesis is an important phenomenon in the tumor growth of maxillary neoplasms. RANK (Receptor Activator of Nuclear Factor κappa B) is the signaling receptor of RANK-L (Receptor activator of nuclear factor kappa-Β ligand) that activates the osteoclasts. OPG (osteoprotegerin) is a decoy receptor for RANK-L that inhibits pro-osteoclastogenesis. The RANK / RANKL / OPG system participates in the regulation of osteolytic activity under normal conditions, and its alteration has been associated with greater bone destruction, and also with tumor growth. Objectives: To analyze the immunohistochemical expression of OPG, RANK and RANK-L proteins in odontogenic myxomas (OMs) and their relationship with the tumor size. Material and Methods: Eighteen OMs, 4 small (<3 cm) and 14 large (> 3cm) and 18 dental follicles (DF) that were included as control were studied by means of standard immunohistochemical procedure with RANK, RANKL and OPG antibodies. For the evaluation, 5 fields (40x) of representative areas of OM and DF were selected where the expression of each antibody was determined. Descriptive and comparative statistical analyses were performed with the obtained data. Results: There are significant differences in the expression of RANK in OM samples as compared to DF (p = 0.022) and among the OMSs and OMLs (p = 0.032). Also a strong association is recognized in the expression of RANK-L and OPG in OM samples. Conclusions: Activation of the RANK / RANK-L / OPG triad seems to be involved in the mechanisms of bone balance and destruction, as well as associated with tumor growth in odontogenic myxomas.
IN: Medicina Oral Patología Oral Cirugía Bucal, 2018, 23(3):315–319.
ISSN: 1698-4447
Citation: González-Galván, M, Mosqueda-Taylor, A, Bologna-Molina, R, Setien-Olarra, A, Marichalar-Mendia, X y Aguirre-Urizar, J. "Evaluation of the osteoclastogenic process associated with RANK / RANK-L / OPG in odontogenic myxomas". Medicina Oral Patología Oral Cirugía Bucal [en línea] 2018, 23(3):315–319.
Appears in Collections:Artículos - Facultad de Odontología

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