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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | González Galván, María del Carmen | es |
dc.contributor.author | Aguirre Urizar, José Manuel | es |
dc.contributor.author | Bologna-Molina, Ronell | es |
dc.contributor.author | Farfán Morales, José Eduardo | es |
dc.contributor.author | Gainza Cirauqui, María Luisa | es |
dc.contributor.author | Marichalar Mendia, Xabier | es |
dc.contributor.author | Mosqueda Taylor, Adalberto | es |
dc.date.accessioned | 2018-03-06T20:32:05Z | - |
dc.date.available | 2018-03-06T20:32:05Z | - |
dc.date.issued | 2016 | es |
dc.date.submitted | 20180305 | es |
dc.identifier.citation | González-Galván, M., Aguirre-Urizar, J., Bologna-Molina, R. y otros. "Assessment of CD-105 as an angiogenic modulator in odontogenic myxomas and dental follicles". International Journal of Surgical Pathology [en linea]. 2016, Vol. 24, no.4, pp. 315-319 | es |
dc.identifier.uri | http://hdl.handle.net/20.500.12008/11116 | - |
dc.description.abstract | Aim. Odontogenic myxoma is a benign intraosseous neoplasm of the jaws, with a locally aggressive behavior and a high recurrence rate. CD-105 is a homodimeric cell membrane glycoprotein and is a component of the TGF-β1 growth factor receptor complex that modulates angiogenesis by regulating the proliferation, differentiation and cellular migration. The aim of this study is to quantify the microvascular density of the odontogenic myxoma based on the expression of CD-105. Materials and Methods. The analysis included 18 odontogenic myxoma and 18 dental follicles as controls. A standard immunohistochemical procedure was performed with the CD-105 antibody. Five representative fields (40×) of the odontogenic myxoma and the dental follicles were selected to determine the microvascular density, which was then followed by a descriptive and comparative statistical analysis. Results. Dental follicles presented a significantly higher microvascular density compared with odontogenic myxoma (P = .001). The odontogenic myxoma smaller than 3 cm showed a greater microvascular density than those larger than 3 cm in size (P > .05), and the microvascular density was lower in large odontogenic myxomas as compared with the dental follicles (P = .003). Conclusion. A weaker expression of CD-105 in odontogenic myxoma might indicate a lower angiogenic activity, suggesting that vascular proliferation has a limited role in the growth mechanisms and in the aggressive behavior of this neoplasm.Aim. Odontogenic myxoma is a benign intraosseous neoplasm of the jaws, with a locally aggressive behavior and a high recurrence rate. CD-105 is a homodimeric cell membrane glycoprotein and is a component of the TGF-β1 growth factor receptor complex that modulates angiogenesis by regulating the proliferation, differentiation and cellular migration. The aim of this study is to quantify the microvascular density of the odontogenic myxoma based on the expression of CD-105. Materials and Methods. The analysis included 18 odontogenic myxoma and 18 dental follicles as controls. A standard immunohistochemical procedure was performed with the CD-105 antibody. Five representative fields (40×) of the odontogenic myxoma and the dental follicles were selected to determine the microvascular density, which was then followed by a descriptive and comparative statistical analysis. Results. Dental follicles presented a significantly higher microvascular density compared with odontogenic myxoma (P = .001). The odontogenic myxoma smaller than 3 cm showed a greater microvascular density than those larger than 3 cm in size (P > .05), and the microvascular density was lower in large odontogenic myxomas as compared with the dental follicles (P = .003). Conclusion. A weaker expression of CD-105 in odontogenic myxoma might indicate a lower angiogenic activity, suggesting that vascular proliferation has a limited role in the growth mechanisms and in the aggressive behavior of this neoplasm. | es |
dc.format.mimetype | application/pdf | es |
dc.language | en | es |
dc.publisher | SAGE | es |
dc.relation.ispartof | International Journal of Surgical Pathology, Vol. 24, no.4, pp. 315-319 | es |
dc.rights | Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad De La República. (Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014) | es |
dc.title | Assessment of CD-105 as an angiogenic modulator in odontogenic myxomas and dental follicles | es |
dc.type | Artículo | es |
dc.rights.licence | Licencia Creative Common Atribución – No Comercial – Sin Derivadas (CC-BY-NC-ND) | es |
Aparece en las colecciones: | Publicaciones Académicas y científicas hasta 2019 - Facultad de Odontología |
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Bologna_2016_IntJSurgPathol.pdf | 258,12 kB | Adobe PDF | Visualizar/Abrir |
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