Título:
Primordial odontogenic tumor : A systematic review
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Autor:
Bologna-Molina, Ronell
Mosqueda Taylor, Adalberto
Pereira-Prado, Vanesa
Sánchez-Romero, Celeste
González González, Rogelio
Mosqueda Taylor, Adalberto
Pereira-Prado, Vanesa
Sánchez-Romero, Celeste
González González, Rogelio
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Tipo de documento:
Artículo
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Primordial odontogenic tumor
Systematic review
Systematic review
Año de publicación:
2020
Contenido:
Resumen:
Background: The primordial odontogenic tumor (POT) is a recently described benign entity with histopathological
and immunohistochemical features suggesting its origin during early odontogenesis. Aim: To integrate the available
data published on POT into a comprehensive analysis to better define its clinicopathological and molecular features.
Material and Methods: An electronic systematic review was performed up to September 2019 in multiple databases.
Results: A total of 13 publications were included, representing 16 reported cases and 3 molecular studies. The
mean age of the affected patients was 11.6 years (range 2-19), with a slight predominance in males (56.25%). The
posterior mandible was the main location (87.5%), with only two cases affecting the posterior maxilla. All cases
appeared as a radiolucent lesion in close relationship to an unerupted tooth. Recurrences have not been reported
to date. Microscopically, POT comprises fibromyxoid tissue with variable cellularity surrounded by a cuboidal to
columnar odontogenic epithelium but without unequivocal dental hard tissue formation. A delicate fibrous capsule
surrounds (at least partially) the tumor. The epithelial component shows immunohistochemical positivity for amelogenin,
CK19, and CK14, and variable expression of Glut-1, Galectin-3 and Caveolin-1, Vimentin, p-53, PITX2,
Bcl-2, Bax and Survivin; the mesenchymal tissue is positive for Vimentin, CD90, p-53, PITX2, Bcl-2, Bax, and
Survivin, and the subepithelial region exhibits the strong expression of Syndecan-1 and CD34. The Ki-67 index
is low (<5%). The negative or weak expression of dentinogenesis-associated genes could explain the inhibition of
dentin and subsequent enamel formation in this neoplasm.
Conclusion: POT is an entity with a well-defined clinicopathological, immunohistochemical and molecular profile
that must be properly diagnosed and differentiated from other odontogenic lesions and treated consequently.
Descripción:
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EN:
Medicina Oral, Patología oral y Cirugía Bucal, 2020, May; 25(3): e388–e394.
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Citación:
Bologna-Molina, R, Mosqueda Taylor, A, Pereira-Prado, V, y otros. "Primordial odontogenic tumor : A systematic review". Medicina Oral, Patología Bucal y Cirugía Bucal.[en línea] 2020, May; 25(3): e388–e394. doi:10.4317/medoral.23432
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ISSN:
1698-6946
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Licencia Creative Commons Atribución - No Comercial (CC - By-NC 4.0)
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| Ficheros | Descripción | Tamaño | Formato | ||
|---|---|---|---|---|---|
| Primordial odontogenic 2020.pdf | — | 1.37 MB | Adobe PDF |