| Metadato | Etiqueta | Valor | Idioma |
|---|---|---|---|
| dc.contributor.author | Autor | Bologna-Molina, Ronell | - |
| dc.contributor.author | Autor | Mosqueda Taylor, Adalberto | - |
| dc.contributor.author | Autor | Pereira-Prado, Vanesa | - |
| dc.contributor.author | Autor | Sánchez-Romero, Celeste | - |
| dc.contributor.author | Autor | González González, Rogelio | - |
| dc.contributor.filiacion | Filiación | Bologna-Molina Ronell, Universidad de la República (Uruguay). Facultad de Odontología | - |
| dc.contributor.filiacion | Filiación | Mosqueda Taylor Adalberto | - |
| dc.contributor.filiacion | Filiación | Pereira-Prado Vanesa, Universidad de la República (Uruguay). Facultad de Odontología | - |
| dc.contributor.filiacion | Filiación | Sánchez-Romero Celeste, Universidad de la República (Uruguay). Facultad de Odontología | - |
| dc.contributor.filiacion | Filiación | González González Rogelio | - |
| dc.date.accessioned | Fecha ingreso | 2020-11-24T16:27:52Z | - |
| dc.date.available | Fecha disponible | 2020-11-24T16:27:52Z | - |
| dc.date.issued | Año de publicación | 2020 | - |
| dc.description.abstract | Resumen | Background: The primordial odontogenic tumor (POT) is a recently described benign entity with histopathological and immunohistochemical features suggesting its origin during early odontogenesis. Aim: To integrate the available data published on POT into a comprehensive analysis to better define its clinicopathological and molecular features. Material and Methods: An electronic systematic review was performed up to September 2019 in multiple databases. Results: A total of 13 publications were included, representing 16 reported cases and 3 molecular studies. The mean age of the affected patients was 11.6 years (range 2-19), with a slight predominance in males (56.25%). The posterior mandible was the main location (87.5%), with only two cases affecting the posterior maxilla. All cases appeared as a radiolucent lesion in close relationship to an unerupted tooth. Recurrences have not been reported to date. Microscopically, POT comprises fibromyxoid tissue with variable cellularity surrounded by a cuboidal to columnar odontogenic epithelium but without unequivocal dental hard tissue formation. A delicate fibrous capsule surrounds (at least partially) the tumor. The epithelial component shows immunohistochemical positivity for amelogenin, CK19, and CK14, and variable expression of Glut-1, Galectin-3 and Caveolin-1, Vimentin, p-53, PITX2, Bcl-2, Bax and Survivin; the mesenchymal tissue is positive for Vimentin, CD90, p-53, PITX2, Bcl-2, Bax, and Survivin, and the subepithelial region exhibits the strong expression of Syndecan-1 and CD34. The Ki-67 index is low (<5%). The negative or weak expression of dentinogenesis-associated genes could explain the inhibition of dentin and subsequent enamel formation in this neoplasm. Conclusion: POT is an entity with a well-defined clinicopathological, immunohistochemical and molecular profile that must be properly diagnosed and differentiated from other odontogenic lesions and treated consequently. | en |
| dc.format.mimetype | Formato | application/pdf | es |
| dc.identifier.citation | Citación | Bologna-Molina, R, Mosqueda Taylor, A, Pereira-Prado, V, y otros. "Primordial odontogenic tumor : A systematic review". Medicina Oral, Patología Bucal y Cirugía Bucal.[en línea] 2020, May; 25(3): e388–e394. doi:10.4317/medoral.23432 | es |
| dc.identifier.doi | DOI | doi:10.4317/medoral.23432 | - |
| dc.identifier.issn | ISSN | 1698-6946 | - |
| dc.identifier.uri | URI | https://hdl.handle.net/20.500.12008/25939 | - |
| dc.language.iso | Idioma | en | es |
| dc.relation.ispartof | EN | Medicina Oral, Patología oral y Cirugía Bucal, 2020, May; 25(3): e388–e394. | en |
| dc.rights | Derechos | Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014) | es |
| dc.rights.licence | Licencia | Licencia Creative Commons Atribución - No Comercial (CC - By-NC 4.0) | es |
| dc.subject.other | Descriptores | Primordial odontogenic tumor | en |
| dc.subject.other | Descriptores | Systematic review | en |
| dc.title | Título | Primordial odontogenic tumor : A systematic review | en |
| dc.type | Tipo de documento | Artículo | es |
Colecciones:
| Ficheros | Descripción | Tamaño | Formato | ||
|---|---|---|---|---|---|
| Primordial odontogenic 2020.pdf | — | 1.37 MB | Adobe PDF |