Título:
Home, head direction stability, and grid cell distortion
Otros títulos:
Coordinador:
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Compilador:
Autor:
Sanguinetti Scheck, Juan Ignacio
Brecht, M.
Brecht, M.
Tutor:
Tipo de documento:
Artículo
Editor:
Palabras clave:
Grid cell
Head direction
Home
Homing
Navigation
Head direction
Home
Homing
Navigation
Descriptores:
Año de publicación:
2020
Contenido:
Resumen:
The home is a unique location in the life of humans and animals. In rats, home presents itself as a multicompartmental space that involves integrating navigation through subspaces. Here we embedded the laboratory rat’s home cage in the arena, while recording neurons in the animal’s parasubiculum and medial entorhinal cortex, two brain areas encoding the animal’s location and head direction. We found that head direction signals were unaffected by home cage presence or translocation. Head direction cells remain globally stable and have similar properties inside and outside the embedded home. We did not observe egocentric bearing encoding of the home cage. However, grid cells were distorted in the presence of the home cage. While they did not globally remap, single firing fields were translocated toward the home. These effects appeared to be geometrical in nature rather than a home-specific distortion and were not dependent on explicit behavioral use of the home cage during a hoarding task. Our work suggests that medial entorhinal cortex and parasubiculum do not remap after embedding the home, but local changes in grid cell activity overrepresent the embedded space location and might contribute to navigation in complex environments.
Descripción:
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Editorial:
American Physiological Society
EN:
Journal of Neurophysiology, 2020, 123(4): 1392–1406
Financiadores:
Citación:
Sanguinetti Scheck, J y Brecht, M. "Home, head direction stability, and grid cell distortion". Journal of Neurophysiology. [en línea] 2020, 123(4): 1392–1406. 15 h. DOI: 10.1152/jn.00518.2019
Citación:
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ISBN:
e-ISBN:
ISSN:
1522-1598
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Licencia:
Licencia Creative Commons Atribución (CC - By 4.0)
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| Ficheros | Descripción | Tamaño | Formato | ||
|---|---|---|---|---|---|
| 10.1152jn.00518.2019.pdf | — | 4.35 MB | Adobe PDF |