Título:
Detection and genetic characterization of Bovine Torovirus in Uruguay
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Autor:
Castells Bauer, Matías
Benítez-Galeano, María José
Marandino, Ana
Caffarena, Rubén Darío
Casaux, María Laura
Pérez Crossa, Ruben Gustavo
Giannitti, Federico
Colina, Rodney
Benítez-Galeano, María José
Marandino, Ana
Caffarena, Rubén Darío
Casaux, María Laura
Pérez Crossa, Ruben Gustavo
Giannitti, Federico
Colina, Rodney
Tutor:
Tipo de documento:
Artículo
Editor:
Palabras clave:
Bovine torovirus
Cattle
Complete genome
Genetic diversity
Evolution
Cattle
Complete genome
Genetic diversity
Evolution
Descriptores:
Año de publicación:
2024
Contenido:
Resumen:
Bovine torovirus (BToV) is an enteric pathogen that may cause diarrhea in calves and adult cattle, which could result in economic losses due to weight loss and decreased milk production. This study aimed to report the presence, the genetic characterization and the evolution of BToV in calves in Uruguay. BToV was detected in 7.9% (22/278) of fecal samples, being identified in dairy (9.2%, 22/239) but not beef (0.0%, 0/39) calves. BToV was detected in both diarrheic (14%, 6/43) and non-diarrheic (13.2%, 5/38) dairy calves. In addition, BToV was detected in the intestinal contents of 14.9% (7/47) of naturally deceased dairy calves. A complete genome (28,446 nucleotides) was obtained, which was the second outside Asia and the first in Latin America. In addition, partial S gene sequences were obtained to perform evolutionary analyses. Nucleotide and amino acid substitutions within and between outbreaks/farms were observed, alerting the continuous evolution of the virus. Through Bayesian analysis using BEAST, a recent origin (mid-60s) of BToV, possibly in Asia, was estimated, with two introductions into Uruguay from Asia and Europe in 2004 and 2013, respectively. The estimated evolutionary rate was 1.80 × 10−3 substitutions/site/year. Our findings emphasize the importance of continued surveillance and genetic characterization for the effective management and understanding of BToV’s global epidemiology and evolution.
Descripción:
metadata.articulos.dc.description.uri:
Editorial:
MDPI
EN:
Viruses, 2024, 16: 835.
Financiadores:
ANII: FCE_3_2022_1_172734
ANII: FMV_1_2014_104922
ANII: FMV_1_2014_104922
Citación:
Castells Bauer, M, Benítez Galeano, M, Marandino, A [y otros autores]. "Detection and genetic characterization of Bovine Torovirus in Uruguay". Viruses. [en línea] 2024, 16: 835. 10 h. DOI: 10.3390/v16060835
Citación:
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ISBN:
e-ISBN:
ISSN:
1999-4915
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Otros identificadores:
Cobertura geográfica:
Uruguay
Cobertura temporal:
Departamento académico:
Grupo de investigación:
Licencia:
Licencia Creative Commons Atribución (CC - By 4.0)
Colecciones:
| Ficheros | Descripción | Tamaño | Formato | ||
|---|---|---|---|---|---|
| 10.3390-v16060835.pdf | — | 1.37 MB | Adobe PDF |