Título:
Transcriptomics of meiosis in the male mouse
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Autor:
Geisinger Wschebor, Adriana
Rodríguez-Casuriaga, Rosana
Benavente, Ricardo
Rodríguez-Casuriaga, Rosana
Benavente, Ricardo
Tutor:
Tipo de documento:
Artículo
Editor:
Palabras clave:
Meiosis
Transcriptomics
RNAseq
Meiotic prophase
Spermatogenesis
lncRNAs
MSCI
Spermatogenic cell sorting
Transcriptomics
RNAseq
Meiotic prophase
Spermatogenesis
lncRNAs
MSCI
Spermatogenic cell sorting
Descriptores:
Año de publicación:
2021
Contenido:
Resumen:
Molecular studies of meiosis in mammals have been long relegated due to some intrinsic obstacles, namely the impossibility to reproduce the process in vitro, and the difficulty to obtain highly pure isolated cells of the different meiotic stages. In the recent years, some technical advances, from the improvement of flow cytometry sorting protocols to single-cell RNAseq, are enabling to profile the transcriptome and its fluctuations along the meiotic process. In this mini-review we will outline the diverse methodological approaches that have been employed, and some of the main findings that have started to arise from these studies. As for practical reasons most studies have been carried out in males, and mostly using mouse as a model, our focus will be on murine male meiosis, although also including specific comments about humans. Particularly, we will center on the controversy about gene expression during early meiotic prophase; the widespread existing gap between transcription and translation in meiotic cells; the expression patterns and potential roles of meiotic long non-coding RNAs; and the
visualization of meiotic sex chromosome inactivation from the RNAseq perspective.
Descripción:
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Editorial:
Frontiers Media
EN:
Frontiers in Cell and Developmental Biology, 2021, 9: art. 626020
Financiadores:
CSIC: I+ D Groups 2018
Citación:
Geisinger Wschebor, A, Rodríguez-Casuriaga, R y Benavente, R. "Transcriptomics of meiosis in the male mouse". Frontiers in Cell and Developmental Biology. [en línea] 2021, 9: art. 626020. 14 h. DOI: 10.3389/fcell.2021.626020
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ISSN:
2352-3409
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Licencia:
Licencia Creative Commons Atribución - No Comercial - Sin Derivadas (CC - By-NC-ND 4.0)
Colecciones:
| Ficheros | Descripción | Tamaño | Formato | ||
|---|---|---|---|---|---|
| 103389fcell2021626020.pdf | — | 2.51 MB | Adobe PDF |