| Metadato | Etiqueta | Valor | Idioma |
|---|---|---|---|
| dc.contributor.author | Autor | Geisinger Wschebor, Adriana | - |
| dc.contributor.author | Autor | Rodríguez-Casuriaga, Rosana | - |
| dc.contributor.author | Autor | Benavente, Ricardo | - |
| dc.contributor.filiacion | Filiación | Geisinger Wschebor Adriana, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología. | - |
| dc.contributor.filiacion | Filiación | Rodríguez-Casuriaga Rosana, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología. | - |
| dc.contributor.filiacion | Filiación | Benavente Ricardo, University of Würzburg | - |
| dc.date.accessioned | Fecha ingreso | 2023-08-18T12:13:38Z | - |
| dc.date.available | Fecha disponible | 2023-08-18T12:13:38Z | - |
| dc.date.issued | Año de publicación | 2021 | - |
| dc.description.abstract | Resumen | Molecular studies of meiosis in mammals have been long relegated due to some intrinsic obstacles, namely the impossibility to reproduce the process in vitro, and the difficulty to obtain highly pure isolated cells of the different meiotic stages. In the recent years, some technical advances, from the improvement of flow cytometry sorting protocols to single-cell RNAseq, are enabling to profile the transcriptome and its fluctuations along the meiotic process. In this mini-review we will outline the diverse methodological approaches that have been employed, and some of the main findings that have started to arise from these studies. As for practical reasons most studies have been carried out in males, and mostly using mouse as a model, our focus will be on murine male meiosis, although also including specific comments about humans. Particularly, we will center on the controversy about gene expression during early meiotic prophase; the widespread existing gap between transcription and translation in meiotic cells; the expression patterns and potential roles of meiotic long non-coding RNAs; and the visualization of meiotic sex chromosome inactivation from the RNAseq perspective. | es |
| dc.description.sponsorship | Financiadores | CSIC: I+ D Groups 2018 | es |
| dc.format.extent | Extensión | 14 h. | es |
| dc.format.mimetype | Formato | application/pdf | es |
| dc.identifier.citation | Citación | Geisinger Wschebor, A, Rodríguez-Casuriaga, R y Benavente, R. "Transcriptomics of meiosis in the male mouse". Frontiers in Cell and Developmental Biology. [en línea] 2021, 9: art. 626020. 14 h. DOI: 10.3389/fcell.2021.626020 | es |
| dc.identifier.doi | DOI | 10.3389/fcell.2021.626020 | - |
| dc.identifier.issn | ISSN | 2352-3409 | - |
| dc.identifier.uri | URI | https://hdl.handle.net/20.500.12008/39521 | - |
| dc.language.iso | Idioma | en | es |
| dc.publisher | Editorial | Frontiers Media | es |
| dc.relation.ispartof | EN | Frontiers in Cell and Developmental Biology, 2021, 9: art. 626020 | es |
| dc.rights | Derechos | Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014) | es |
| dc.rights.licence | Licencia | Licencia Creative Commons Atribución - No Comercial - Sin Derivadas (CC - By-NC-ND 4.0) | es |
| dc.subject | Palabras clave | Meiosis | es |
| dc.subject | Palabras clave | Transcriptomics | es |
| dc.subject | Palabras clave | RNAseq | es |
| dc.subject | Palabras clave | Meiotic prophase | es |
| dc.subject | Palabras clave | Spermatogenesis | es |
| dc.subject | Palabras clave | lncRNAs | es |
| dc.subject | Palabras clave | MSCI | es |
| dc.subject | Palabras clave | Spermatogenic cell sorting | es |
| dc.title | Título | Transcriptomics of meiosis in the male mouse | es |
| dc.type | Tipo de documento | Artículo | es |
Colecciones:
| Ficheros | Descripción | Tamaño | Formato | ||
|---|---|---|---|---|---|
| 103389fcell2021626020.pdf | — | 2.51 MB | Adobe PDF |