Título:
Radiolysis Studies of Oxidation and Nitration of Tyrosine and Some Other Biological Targets by Peroxynitrite‐Derived Radicals
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Autor:
Folkes, Lisa K.
Bartesaghi, Silvina
Trujillo, Madia
Wardman, Peter
Radi, Rafael
Bartesaghi, Silvina
Trujillo, Madia
Wardman, Peter
Radi, Rafael
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Tipo de documento:
Artículo
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Palabras clave:
Radiolysis
Hydroxyl radicals
Carbonate radicals
Nitrogen dioxide radicals
Tyrosine
Dityrosine
Nitric oxide
Nitrotyrosine
Lipoic acid
Hydrogen sulfide
DMPO
Desferrioxiamine
Hydroxyl radicals
Carbonate radicals
Nitrogen dioxide radicals
Tyrosine
Dityrosine
Nitric oxide
Nitrotyrosine
Lipoic acid
Hydrogen sulfide
DMPO
Desferrioxiamine
Descriptores:
TIROSINA
ÓXIDO NÍTRICO
RADIÓLISIS DE IMPULSO
FENÓMENOS QUÍMICOS ORGÁNICOS
OXIDACIÓN
ÁCIDO PEROXINITROSO
SULFURO DE HIDRÓGENO
ÁCIDO TIÓCTICO
ÓXIDO NÍTRICO
RADIÓLISIS DE IMPULSO
FENÓMENOS QUÍMICOS ORGÁNICOS
OXIDACIÓN
ÁCIDO PEROXINITROSO
SULFURO DE HIDRÓGENO
ÁCIDO TIÓCTICO
Año de publicación:
2022
Contenido:
Resumen:
The widespread interest in free radicals in biology extends far beyond the effects of ionizing radiation, with recent attention largely focusing on reactions of free radicals derived from peroxynitrite (i.e., hydroxyl, nitrogen dioxide, and carbonate radicals). These radicals can easily be generated individually by reactions of radiolytically-produced radicals in aqueous solutions and their reactions can be monitored either in real time or by analysis of products. This review first describes the general principles of selective radical generation by radiolysis, the yields of individual species, the advantages and limitations of either pulsed or continuous radiolysis, and the quantitation of oxidizing power of radicals by electrode potentials. Some key reactions of peroxynitrite-derived radicals with potential biological targets are then discussed, including the characterization of reactions of tyrosine with a model alkoxyl radical, reactions of tyrosyl radicals with nitric oxide, and routes to nitrotyrosine formation. This is followed by a brief outline of studies involving the reactions of peroxynitrite-derived radicals with lipoic acid/dihydrolipoic acid, hydrogen sulphide, and the metal chelator desferrioxamine. For biological diagnostic probes such as ‘spin traps’ to be used with confidence, their reactivities with radical species have to be characterized, and the application of radiolysis methods in this context is also illustrated.
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MDPI
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International Journal of Molecular Sciences. 2022;23(3)
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Citación:
Folkes L, Bartesaghi S, Trujillo M y otros. Radiolysis Studies of Oxidation and Nitration of Tyrosine and Some Other Biological Targets by Peroxynitrite‐Derived Radicals. International Journal of Molecular Sciences [en línea]. 2022;23(3). 16 p.
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Licencia Creative Commons Atribución (CC - By 4.0)
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| Ficheros | Descripción | Tamaño | Formato | ||
|---|---|---|---|---|---|
| Radiolysis Studies of Oxidation and Nitration of Tyrosine.pdf | Radiolysis Studies of Oxidation and Nitration of Tyrosine | 26.91 MB | Adobe PDF |