Radiolysis Studies of Oxidation and Nitration of Tyrosine and Some Other Biological Targets by Peroxynitrite‐Derived Radicals

Folkes, Lisa K.; Bartesaghi, Silvina; Trujillo, Madia; Wardman, Peter; Radi, Rafael

doi:10.3390/ijms23031797

Metadato	Etiqueta	Valor	Idioma
dc.contributor.author	Autor	Folkes, Lisa K.	-
dc.contributor.author	Autor	Bartesaghi, Silvina	-
dc.contributor.author	Autor	Trujillo, Madia	-
dc.contributor.author	Autor	Wardman, Peter	-
dc.contributor.author	Autor	Radi, Rafael	-
dc.contributor.filiacion	Filiación	Folkes Lisa K., University of Oxford (Reino Unido)	-
dc.contributor.filiacion	Filiación	Bartesaghi Silvina, Universidad de la República (Uruguay). Facultad de Medicina. Departamento de Bioquímica y Centro de Investigaciones Biomédicas (CEINBIO)	-
dc.contributor.filiacion	Filiación	Trujillo Madia, Universidad de la República (Uruguay). Facultad de Medicina. Departamento de Bioquímica y Centro de Investigaciones Biomédicas (CEINBIO)	-
dc.contributor.filiacion	Filiación	Wardman Peter, University of Oxford (Reino Unido)	-
dc.contributor.filiacion	Filiación	Radi Rafael, Universidad de la República (Uruguay). Facultad de Medicina. Departamento de Bioquímica y Centro de Investigaciones Biomédicas (CEINBIO)	-
dc.date.accessioned	Fecha ingreso	2026-05-25T19:13:39Z	-
dc.date.available	Fecha disponible	2026-05-25T19:13:39Z	-
dc.date.issued	Año de publicación	2022	-
dc.description.abstract	Resumen	The widespread interest in free radicals in biology extends far beyond the effects of ionizing radiation, with recent attention largely focusing on reactions of free radicals derived from peroxynitrite (i.e., hydroxyl, nitrogen dioxide, and carbonate radicals). These radicals can easily be generated individually by reactions of radiolytically-produced radicals in aqueous solutions and their reactions can be monitored either in real time or by analysis of products. This review first describes the general principles of selective radical generation by radiolysis, the yields of individual species, the advantages and limitations of either pulsed or continuous radiolysis, and the quantitation of oxidizing power of radicals by electrode potentials. Some key reactions of peroxynitrite-derived radicals with potential biological targets are then discussed, including the characterization of reactions of tyrosine with a model alkoxyl radical, reactions of tyrosyl radicals with nitric oxide, and routes to nitrotyrosine formation. This is followed by a brief outline of studies involving the reactions of peroxynitrite-derived radicals with lipoic acid/dihydrolipoic acid, hydrogen sulphide, and the metal chelator desferrioxamine. For biological diagnostic probes such as ‘spin traps’ to be used with confidence, their reactivities with radical species have to be characterized, and the application of radiolysis methods in this context is also illustrated.	es
dc.format.extent	Extensión	16 p.	es
dc.format.mimetype	Formato	application/pdf	es
dc.identifier.citation	Citación	Folkes L, Bartesaghi S, Trujillo M y otros. Radiolysis Studies of Oxidation and Nitration of Tyrosine and Some Other Biological Targets by Peroxynitrite‐Derived Radicals. International Journal of Molecular Sciences [en línea]. 2022;23(3). 16 p.	es
dc.identifier.doi	DOI	10.3390/ijms23031797	-
dc.identifier.eissn	e-ISSN	1422-0067	-
dc.identifier.uri	URI	https://hdl.handle.net/20.500.12008/55192	-
dc.language.iso	Idioma	en	es
dc.publisher	Editorial	MDPI	es
dc.relation.ispartof	EN	International Journal of Molecular Sciences. 2022;23(3)	es
dc.rights	Derechos	Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014)	es
dc.rights.licence	Licencia	Licencia Creative Commons Atribución (CC - By 4.0)	es
dc.subject	Palabras clave	Radiolysis	es
dc.subject	Palabras clave	Hydroxyl radicals	es
dc.subject	Palabras clave	Carbonate radicals	es
dc.subject	Palabras clave	Nitrogen dioxide radicals	es
dc.subject	Palabras clave	Tyrosine	es
dc.subject	Palabras clave	Dityrosine	es
dc.subject	Palabras clave	Nitric oxide	es
dc.subject	Palabras clave	Nitrotyrosine	es
dc.subject	Palabras clave	Lipoic acid	es
dc.subject	Palabras clave	Hydrogen sulfide	es
dc.subject	Palabras clave	DMPO	es
dc.subject	Palabras clave	Desferrioxiamine	es
dc.subject.other	Descriptores	TIROSINA	es
dc.subject.other	Descriptores	ÓXIDO NÍTRICO	es
dc.subject.other	Descriptores	RADIÓLISIS DE IMPULSO	es
dc.subject.other	Descriptores	FENÓMENOS QUÍMICOS ORGÁNICOS	es
dc.subject.other	Descriptores	OXIDACIÓN	es
dc.subject.other	Descriptores	ÁCIDO PEROXINITROSO	es
dc.subject.other	Descriptores	SULFURO DE HIDRÓGENO	es
dc.subject.other	Descriptores	ÁCIDO TIÓCTICO	es
dc.title	Título	Radiolysis Studies of Oxidation and Nitration of Tyrosine and Some Other Biological Targets by Peroxynitrite‐Derived Radicals	es
dc.type	Tipo de documento	Artículo	es

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