https://hdl.handle.net/20.500.12008/43698 Reúne artículos científicos, así como capítulos de libros en donde por lo menos uno de sus autores pertenece a la Facultad de Odontología, desde el año 2020. 2026-04-23T10:31:00Z https://hdl.handle.net/20.500.12008/54152 Título: Cyclooxygenase-2 selective inhibitors increase the risk of alveolar osteitis: a systematic review and meta-analysis. Autor: Isiordia-Espinoza, Mario Alberto; Hernández Gómez, Adriana; Bologna-Molina, Ronell; Serafín-Higuera, Nicolás; Molina-Frechero, Nelly; Gómez Sánchez, Eduardo; López-Verdín, Sandra; Guzmán-Flores, Juan Manuel Resumen: Background: The purpose of this systematic review was to determine the risk of alveolar osteitis with the use of traditional non-steroidal anti-inflammatory analgesics (NSAIDs) and COX-2 selective inhibitors compared to placebo using data from published clinical trials. Material and Methods: Embase and Medline/PubMed databases were employed to search for clinical trials. Articles that met the inclusion criteria were assessed for risk of bias using the Cochrane tool and data on alveolar osteitis were specifically extracted. Statistical analysis was performed using Review Manager 5.3 software. Results: The risk assessment for alveolar osteitis concerning traditional NSAIDs included 19 clinical trials (n=2888) while for COX-2 inhibitors included 13 clinical trials (n=3820). Overall statistical analysis and subgroup evaluation by medication indicated that traditional NSAIDs did not increase the risk of alveolar osteitis. On the other hand, subgroup statistical analysis for selective COX-2 inhibitors suggested that rofecoxib elevated a patient's risk of developing alveolar osteitis (n=947, I2=0%, Z=2.52, OR=1.89, 95% CI=1.15 to 3.10, p=0.01) compared with placebo. Sensitivity analysis of the rofecoxib data exhibited high statistical robustness. Conclusions: Data indicates that rofecoxib increases the risk of alveolar osteitis in patients undergoing tooth extraction. Descripción: Article in press. 2026-01-01T00:00:00Z https://hdl.handle.net/20.500.12008/54089 Título: Protección ocular en el ejercicio de la odontología. Autor: Rotemberg, Enrique; Aldabalde, Macarena Resumen: La visión es una herramienta crítica para la precisión en la práctica odontológica; sin embargo, los profesionales de salud están expuestos a múltiples agentes de riesgo ocular: químicos, biológicos, radiaciones ópticas y mecánicos. A pesar de la disponibilidad de equipos de protección personal, la literatura revela una adopción irregular de medidas preventivas. El objetivo general del presente artículo de interés para la comunidad científica es describir los agentes injuriantes más frecuentes en la actividad profesional para el odontólogo, el higienista en odontología, el asistente en odontología y el propio paciente. El estudio integra la evidencia reciente y clásica sobre lesiones oculares ocupacionales en odontología, analiza los mecanismos fisiopatológicos desde la oftalmología y propone estrategias de prevención basadas en la jerarquía de control. Se enfatiza la necesidad de protocolos estandarizados de bioseguridad ocular, la formación interdisciplinaria con oftalmología y la vigilancia periódica de la salud visual del profesional de la salud bucodental.; Vision is a critical tool for precision in dental practice; however, healthcare professionals are exposed to multiple eye risk agents: chemical, biological, optical radiation, and mechanical. Despite the availability of personal protective equipment, the literature reveals inconsistent adoption of preventive measures. The overall objective of this article, which is of interest to the scientific community, is to describe the most common harmful agents in the professional activities of dentists, dental hygienists, dental assistants, and patients themselves. The study integrates recent and classic evidence on occupational eye injuries in dentistry, analyzes pathophysiological mechanisms from an ophthalmological perspective, and proposes prevention strategies based on the hierarchy of control. It emphasizes the need for standardized eye biosafety protocols, interdisciplinary training with ophthalmology, and regular monitoring of the visual health of oral health professionals. 2025-01-01T00:00:00Z https://hdl.handle.net/20.500.12008/54022 Título: Differences of immunohistochemical profiling of MOC-31, caveolin-1, connexin-43, Ki-67 in ameloblastic fibroma, ameloblastic fibrodentinoma, ameloblastic fibro-odontoma, and odontomas. Autor: González Umpiérrez, María Natalia; Sicco, Estefanía; Silveira, Felipe Martins; Beovide Cortegoso, Verónica; Bologna-Molina, Ronell Resumen: Odontogenic tumors are a heterogeneous group of lesions originating from tissues involved in odontogenesis. Mixed odontogenic tumors comprise a group of lesions characterized by the presence of ectodermal and mesenchymal odontogenic tissues with or without the formation of hard dental tissues. Aim: To determine and compare the expression of caveolin-1, MOC-31, connexin-43 (Cx-43), and Ki-67 in ameloblastic fibromas (AF), ameloblastic fibrodentinomas (AFD), ameloblastic fibro-odontomas (AFO), and odontomas (O). Methods: Immunohistochemical analysis for caveolin-1, MOC-31, Cx-43, and Ki-67 was performed on eight AF, one AFD, five AFO, and six O. RESULTS Variable protein expression was identified in the epithelium and mesenchyme of most AF, AFD, and AFO with lower expression observed in O. Immunohistochemical analysis revealed significant differences in protein expression between AF and O (P = 0.0085) and between AFO/AFD and O (P = 0.0250). When evaluating individual proteins, a significant difference in MOC-31 expression was observed between AF and O (P = 0.0310), while Cx-43 expression differed between AFO/AFD and O (P = 0.0022) and between AF and O (P = 0.0310). Additionally, protein expression decreased with increasing age (P ≤ 0.0100). Conclusion: This immunohistochemical study suggested that the similarity in protein expression between AFD, AFO, and AF compared with O may be due to the biological proximity among these lesions at the protein expression level. Further studies with larger sample sizes and complementary techniques are required to validate these findings. 2026-01-01T00:00:00Z https://hdl.handle.net/20.500.12008/53873 Título: Algorithmic analysis of the structure of mixed odontogenic tumors. Autor: Pereira-Prado, Vanesa; Sicco, Estefanía; Silveira, Felipe Martins; Schuch, Lauren Frenzel; Hunter, Keith; Niklander, Sven E.; Tilakaratne, Wanninayake Mudiyanselage; Gomez, Ricardo Santiago; Landini, Gabriel; Bologna-Molina, Ronell Resumen: Aims: This study aims to characterize the histomorphology of mixed odontogenic tumors, using mathematical morphology algorithms applied to digital images. Methods: Five cases of primordial odontogenic tumor (POT), 5 cases of ameloblastic fibroma, 5 cases of developing odontoma (DO), and 5 cases of tooth germs (TG) were analyzed. Histological sections stained with Haematoxylin & Eosin were digitized and the epithelial compartments were segmented into ‘virtual cells’ to further characterize the tissue compartment architecture. Results: A comparison of the mean area of virtual epithelial cells in the entities investigated showed that, despite data distribution between the entities being similar, statistically significant differences (p<0.001) were found, being larger for DO and smaller for AF. Additionally, DO exhibits a broader data distribution of the area compared to the other entities. Significant differences were not found between TG and POT without subepithelial condensation. Conclusions: Quantitative tissue analysis showed that, in focal areas, POT more closely resembles TG than other mixed odontogenic tumors. These findings suggest that virtual cell–based morphometric analysis may provide complementary quantitative information in diagnostically challenging cases, although validation in larger datasets is required. Descripción: Article in press. 2026-01-01T00:00:00Z