| Metadato | Etiqueta | Valor | Idioma |
|---|---|---|---|
| dc.contributor.author | Autor | Pessina Serdio, Ana Paula | - |
| dc.contributor.author | Autor | Fernández Foren, Andrea | - |
| dc.contributor.author | Autor | Cueto Rostom, Enrique | - |
| dc.contributor.author | Autor | Delucchi, Luis | - |
| dc.contributor.author | Autor | Castillo, Víctor Alejandro | - |
| dc.contributor.author | Autor | Meikle, Ana | - |
| dc.contributor.filiacion | Filiación | Pessina Serdio Ana Paula, Universidad de la República (Uruguay). Facultad de Veterinaria. Laboratorio de Técnicas Nucleares | - |
| dc.contributor.filiacion | Filiación | Fernández Foren Andrea, Universidad de la República (Uruguay). Facultad de Veterinaria. Laboratorio de Técnicas Nucleares | - |
| dc.contributor.filiacion | Filiación | Cueto Rostom Enrique, Universidad de la República (Uruguay). Facultad de Veterinaria. Clínica de Pequeños Animales | - |
| dc.contributor.filiacion | Filiación | Delucchi Luis, Universidad de la República (Uruguay). Facultad de Veterinaria. Clínica de Pequeños Animales | - |
| dc.contributor.filiacion | Filiación | Castillo Víctor Alejandro, Universidad de Buenos Aires (Argentina). U. Endocrinología. Hospital Escuela. Area de Clínica Médica de Pequeños Animales | - |
| dc.contributor.filiacion | Filiación | Meikle Ana, Universidad de la República (Uruguay). Facultad de Veterinaria. Laboratorio de Técnicas Nucleares | - |
| dc.date.accessioned | Fecha ingreso | 2025-07-21T12:22:59Z | - |
| dc.date.available | Fecha disponible | 2025-07-21T12:22:59Z | - |
| dc.date.issued | Año de publicación | 2009 | - |
| dc.description.abstract | Resumen | Background: For the conclusive diagnosis of Cushing's Syndrome, a stimulating ACTH test or a low suppressive Dexamethasone test is used. Reports in other species than the dog indicate that plasma cortisol concentration after ACTH administration is affected by gender. We investigated the effect of gender on the cortisol response to ACTH and Dexamethasone tests in dogs. Methods: Seven healthy adult Cocker Spaniels (4 females and 3 males) were assigned to a two by two factorial design: 4 dogs (2 females and 2 males) received IV Dexamethasone 0.01 mg/kg, while the other 3 dogs received an IV saline solution (control group). Two weeks later the treatments were reversed. After one month, ACTH was given IV (250 μg/animal) to 4 dogs (2 female and 2 males) while the rest was treated with saline solution (control group). Cortisol concentrations were determined by a direct solid-phase radioimmunoassay and cholesterol and triglycerides by commercial kits. Results and Discussion: No effect of treatment was observed in metabolite concentrations, but females presented higher cholesterol concentrations. ACTH-treated dogs showed an increase in cortisol levels in the first hour after sampling until 3 hours post injection. Cortisol concentrations in Dexamethasone-treated dogs decreased one hour post injection and remained low for 3 hours, thereafter cortisol concentrations increased. The increase in cortisol levels from one to two hours post ACTH injection was significantly higher in females than males. In Dexamethasone-treated males cortisol levels decreased one hour post injection up to 3 hours; in females the decrease was more pronounced and prolonged, up to 5 hours post injection. Conclusion: We have demonstrated that cortisol response to ACTH and Dexamethasone treatment in dogs differs according to sex. | es |
| dc.format.extent | Extensión | 6 p | es |
| dc.format.mimetype | Formato | application/pdf | es |
| dc.identifier.citation | Citación | Pessina Serdio, A, Fernández Foren, A, Cueto Rostom, E, Delucchi, L, Castillo, V y Meikle, A. Cortisol secretion after adrenocorticotrophin (ACTH) and Dexamethasone tests in healthy female and male dogs. Acta Veterinaria Scandinavica. [en línea] 2009, 51(33), 1-6 | es |
| dc.identifier.doi | DOI | 10.1186/1751-0147-51-33 | - |
| dc.identifier.uri | URI | https://hdl.handle.net/20.500.12008/50678 | - |
| dc.language.iso | Idioma | en | es |
| dc.relation.ispartof | EN | Acta Veterinaria Scandinavica, 2009, 51(33), 1-6 | es |
| dc.rights | Derechos | Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014) | es |
| dc.rights.licence | Licencia | Licencia Creative Commons Atribución - No Comercial - Sin Derivadas (CC - By-NC-ND 4.0) | es |
| dc.subject.other | Descriptores | PERROS | es |
| dc.subject.other | Descriptores | PEQUEÑOS ANIMALES | es |
| dc.subject.other | Descriptores | HORMONAS | es |
| dc.subject.other | Descriptores | ADRENOCORTICOTROPICAS | es |
| dc.subject.other | Descriptores | SINDROME DE CUSHING | es |
| dc.subject.other | Descriptores | DEXAMETASONA | es |
| dc.title | Título | Cortisol secretion after adrenocorticotrophin (ACTH) and Dexamethasone tests in healthy female and male dogs | es |
| dc.type | Tipo de documento | Artículo | es |
Colecciones:
| Ficheros | Descripción | Tamaño | Formato | ||
|---|---|---|---|---|---|
| M27.pdf | — | 313 KB | Adobe PDF |