Título:
Synthesis of a [18F]F Estradiol Derivative via Click Chemistry Using an Automated Synthesis Module : In Vitro Evaluation as Potential Radiopharmaceutical for Breast Cancer Imaging
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Autor:
Tejería, María Emilia
Pereira, María Pía
Gambini, Juan Pablo
Duarte, Pablo
Giglio, Javier Gabriel
Rey, Ana María
Pereira, María Pía
Gambini, Juan Pablo
Duarte, Pablo
Giglio, Javier Gabriel
Rey, Ana María
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Artículo
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RADIOFARMACOS
CANCER DE MAMA
IMAGENES
QUIMICA CLIC
REACCIONES QUIMICAS
CANCER DE MAMA
IMAGENES
QUIMICA CLIC
REACCIONES QUIMICAS
Año de publicación:
2024
Contenido:
Resumen:
“Click reactions” are a very useful tool for the selective conjugation of different molecular subunits to produce complex structures in a simple way. In this paper, we present the application of Cu(I)-catalyzed biorthogonal reactions between alkynes and azides to the indirect radiofluorination of an estradiol derivative with potential applications in estrogen receptor imaging. The procedure was fully developed on an automated synthesis platform, and conditions were optimized to achieve the desired product with a reasonable yield without precipitation. Although the biological results were not adequate for a potential radiopharmaceutical, the outcome of this work is valuable since the use of automated platforms is required for the reliable and reproducible preparation of PET radiopharmaceuticals in GMP conditions while limiting the radiation dose rates to the personnel.
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Pharmaceuticals, v.17, n°388, 2024. --
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Citación:
Tejería, M, Pereira, M, Gambini, J, Duarte, P, Giglio, J y Rey, A. Synthesis of a [18F]F Estradiol Derivative via Click Chemistry Using an Automated Synthesis Module : In Vitro Evaluation as Potential Radiopharmaceutical for Breast Cancer Imaging. Pharmaceuticals [en línea] v.17, n°388, 2024. -- 17 p.
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Licencia Creative Commons Atribución - No Comercial - Sin Derivadas (CC - By-NC-ND 4.0)
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| Ficheros | Descripción | Tamaño | Formato | ||
|---|---|---|---|---|---|
| Synthesis of a Estradiol Derivative.pdf | — | 3.65 MB | Adobe PDF |